1,4-Dianilinobenzene

Modify Date: 2024-01-02 08:08:23

1,4-Dianilinobenzene Structure
1,4-Dianilinobenzene structure
Common Name 1,4-Dianilinobenzene
CAS Number 74-31-7 Molecular Weight 260.333
Density 1.2±0.1 g/cm3 Boiling Point 469.2±0.0 °C at 760 mmHg
Molecular Formula C18H16N2 Melting Point 143-145 °C(lit.)
MSDS Chinese USA Flash Point 297.0±13.0 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name N,N'-diphenyl-1,4-phenylenediamine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 469.2±0.0 °C at 760 mmHg
Melting Point 143-145 °C(lit.)
Molecular Formula C18H16N2
Molecular Weight 260.333
Flash Point 297.0±13.0 °C
Exact Mass 260.131348
PSA 24.06000
LogP 3.32
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.694
Stability Stable. Incompatible with strong acids, strong oxidizing agents
Water Solubility <0.1 g/100 mL at 20 ºC

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ST2275000
CHEMICAL NAME :
p-Phenylenediamine, N,N'-diphenyl-
CAS REGISTRY NUMBER :
74-31-7
BEILSTEIN REFERENCE NO. :
2215944
LAST UPDATED :
199710
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C18-H16-N2
MOLECULAR WEIGHT :
260.36
WISWESSER LINE NOTATION :
RMR DMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
182 gm/kg/2Y-C
TOXIC EFFECTS :
Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20443 mg/kg/3W-C
TOXIC EFFECTS :
Blood - change in clotting factors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
450 mg/kg
SEX/DURATION :
female 14 day(s) pre-mating female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4176 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
30 mg/L
REFERENCE :
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9(Suppl 2),27,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80282 No. of Facilities: 315 (estimated) No. of Industries: 5 No. of Occupations: 22 No. of Employees: 7496 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80282 No. of Facilities: 139 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 7680 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317-H412
Precautionary Statements P273-P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R43;R52/53
Safety Phrases S24-S37-S61
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS ST2275000
Packaging Group III
Hazard Class 6.1
HS Code 2921590090

 Synthetic Route

 Customs

HS Code 2921590090
Summary 2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles25

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 Synonyms

1,4-Benzenediamine, N,N'-diphenyl-
1,4-benzenediamine, N1,N4-diphenyl-
1-N,4-N-diphenylbenzene-1,4-diamine
N,N'-Diphenyl-1,4-benzenediamine
p-phenylenediamine, N,N'-diphenyl-
dppd
N,N'-Diphenyl-1,4-phenylenediamine
n,n'-diphenylbenzene-1,4-diamine
1,4-Benzenediamine, N,N-diphenyl-
N,N′-Diphenyl-1,4-phenylenediamine
1,4-Dianilinobenzene
N,N′-Diphenyl-p-phenylenediamine
EINECS 200-806-4
n,n'-diphenyl-p-phenylenediamine
1,4-Bis(phenylamino)benzene
MFCD00003015
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