1,4-Dianilinobenzene

Modify Date: 2025-08-21 09:41:35

1,4-Dianilinobenzene structure	Common Name	1,4-Dianilinobenzene
	CAS Number	74-31-7	Molecular Weight	260.333
	Density	1.2±0.1 g/cm3	Boiling Point	469.2±0.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₆N₂	Melting Point	143-145 °C(lit.)
	MSDS	Chinese USA	Flash Point	297.0±13.0 °C
	Symbol	GHS07	Signal Word	Warning

Name	N,N'-diphenyl-1,4-phenylenediamine
Synonym	More Synonyms

Density	1.2±0.1 g/cm3
Boiling Point	469.2±0.0 °C at 760 mmHg
Melting Point	143-145 °C(lit.)
Molecular Formula	C₁₈H₁₆N₂
Molecular Weight	260.333
Flash Point	297.0±13.0 °C
Exact Mass	260.131348
PSA	24.06000
LogP	3.32
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.694
Stability	Stable. Incompatible with strong acids, strong oxidizing agents
Water Solubility	<0.1 g/100 mL at 20 ºC

1,4-Dianilinobenzene MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ST2275000

CHEMICAL NAME :: p-Phenylenediamine, N,N'-diphenyl-

CAS REGISTRY NUMBER :: 74-31-7

BEILSTEIN REFERENCE NO. :: 2215944

LAST UPDATED :: 199710

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C18-H16-N2

MOLECULAR WEIGHT :: 260.36

WISWESSER LINE NOTATION :: RMR DMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 gm/kg/2Y-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20443 mg/kg/3W-C

TOXIC EFFECTS :: Blood - change in clotting factors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 450 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4176 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 30 mg/L

REFERENCE :: SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975- Volume(issue)/page/year: 9(Suppl 2),27,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80282 No. of Facilities: 315 (estimated) No. of Industries: 5 No. of Occupations: 22 No. of Employees: 7496 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80282 No. of Facilities: 139 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 7680 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H412
Precautionary Statements	P273-P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R43;R52/53
Safety Phrases	S24-S37-S61
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	ST2275000
Packaging Group	III
Hazard Class	6.1
HS Code	2921590090

Precursor 8
CAS#:108-90-7 Chlorobenzene CAS#:101-54-2 4-Aminodiphenylamine CAS#:106-50-3 p-Phenylenediamine CAS#:108-86-1 Bromobenzene
CAS#:126150-65-0 benzene-1,4-dio... CAS#:109-79-5 butanethiol CAS#:6246-98-6 N,N'-Diphenyl-1... CAS#:123-31-9 Hydroquinone
DownStream 10
CAS#:14118-16-2 N,N,N',N'-Tetra... CAS#:19606-98-5 N,N,N'-Tripheny... CAS#:4369-14-6 3-acryloxypropy... CAS#:19099-70-8 4-N-[4-(4-anili...
CAS#:2716-09-8 1,4-Benzenediam... CAS#:824-69-1 2,5-DICHLOROHYD... CAS#:6246-98-6 N,N'-Diphenyl-1... CAS#:101-87-1 N-Phenyl-N'-cyc...
CAS#:17754-68-6 1-N,4-N-dimethy... CAS#:88-99-3 Phthalic acid

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Skin sensitization potency and cross-reactivity of p-phenylenediamine and its derivatives evaluated by non-radioactive murine local lymph node assay and guinea-pig maximization test.

Contact Dermatitis 60(4) , 193-8, (2009)

p-Phenylenediamine (PPD)-related chemicals have been used as antioxidants in rubber products, and many cases of contact dermatitis caused by these chemicals have been reported.The aim of this study wa...

Insight into the mechanism of trypanosome lytic factor-1 killing of Trypanosoma brucei brucei.

Mol. Biochem. Parasitol. 118(1) , 33-40, (2001)

It has been known for almost a century that normal human serum can lyse the extracellular blood parasite Trypanosoma brucei brucei. This process is a result of a non-immune killing factor in human ser...

Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells.

Nutr. Cancer 60(2) , 276-83, (2008)

Cultured rat hepatocytes and human hepatoma HepG2 cells were used to evaluate the hepatoprotective properties of polyphenolic extracts from the edible part of artichoke (AE). The hepatocytes were expo...

1,4-Benzenediamine, N,N'-diphenyl-

1,4-benzenediamine, N1,N4-diphenyl-

1-N,4-N-diphenylbenzene-1,4-diamine

N,N'-Diphenyl-1,4-benzenediamine

p-phenylenediamine, N,N'-diphenyl-

dppd

N,N'-Diphenyl-1,4-phenylenediamine

n,n'-diphenylbenzene-1,4-diamine

1,4-Benzenediamine, N,N-diphenyl-

N,N′-Diphenyl-1,4-phenylenediamine

1,4-Dianilinobenzene

N,N′-Diphenyl-p-phenylenediamine

EINECS 200-806-4

n,n'-diphenyl-p-phenylenediamine

1,4-Bis(phenylamino)benzene

MFCD00003015

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1,4-Dianilinobenzene
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1,4-Dianilinobenzene
Price: ￥108.0/25g ￥318.0/100g
Purity: 95.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: N,N'-diphenyl-p-Phenylenediamine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N,N'-Diphenyl-1,4-phenylenediamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: N,N-Diphenyl-p-phenylenediamine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 1,4-Dianilinobenzene
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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1,4-Dianilinobenzene

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

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