Methylnissolin

Modify Date: 2024-01-05 18:36:07

Methylnissolin structure	Common Name	Methylnissolin
	CAS Number	73340-41-7	Molecular Weight	300.306
	Density	1.3±0.1 g/cm3	Boiling Point	428.9±45.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	213.2±28.7 °C

Use of Methylnissolin

Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].

Name	(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Synonym	More Synonyms

Description	Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	PDGFR:10 μM (IC50) ERK1 ERK2
References	[1]. Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7.

Density	1.3±0.1 g/cm3
Boiling Point	428.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₆O₅
Molecular Weight	300.306
Flash Point	213.2±28.7 °C
Exact Mass	300.099762
PSA	57.15000
LogP	2.45
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.612