Methylnissolin

Names

[ Name ]:
Methylnissolin

[Synonym ]:
6H-Benzofuro[3,2-c][1]benzopyran-3-ol, 6a,11a-dihydro-9,10-dimethoxy-
(-)-10-methoxymedicarpin
9,10-Dimethoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
3-hydroxy-9,10-dimethoxypterocarpane
3-hydroxy-9,10-dimethoxypterocarpan
9-methoxynissolin
(-)-methylnissolin
Methylnissolin

Biological Activity

[Description]:

Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

PDGFR:10 μM (IC50)

ERK1

ERK2

[References]

[1]. Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
428.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆O₅

[ Molecular Weight ]:
300.306

[ Flash Point ]:
213.2±28.7 °C

[ Exact Mass ]:
300.099762

[ PSA ]:
57.15000

[ LogP ]:
2.45

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.612

Related Compounds

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