L-Aspartic acid,3-hydroxy-, (3S)-

Modify Date: 2025-09-10 18:57:42

L-Aspartic acid,3-hydroxy-, (3S)- structure	Common Name	L-Aspartic acid,3-hydroxy-, (3S)-
	CAS Number	7298-99-9	Molecular Weight	149.10
	Density	1.738 g/cm3	Boiling Point	368.7ºCat 760 mmHg
	Molecular Formula	C₄H₇NO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	176.8ºC

Use of L-Aspartic acid,3-hydroxy-, (3S)-

L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].

Name	(3S)-3-hydroxy-L-aspartic acid
Synonym	More Synonyms

Description	L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].
Related Catalog	Signaling Pathways >> Others >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2 Research Areas >> Neurological Disease
Target	Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2)[1]
References	[1]. HaraR, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-DeficientEscherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolorA3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54 [2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27.

Density	1.738 g/cm3
Boiling Point	368.7ºCat 760 mmHg
Molecular Formula	C₄H₇NO₅
Molecular Weight	149.10
Flash Point	176.8ºC
Exact Mass	149.03200
PSA	120.85000
Storage condition	Store at RT

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China
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