Calcium oxytetracycline
Modify Date: 2025-08-25 14:19:21
Calcium oxytetracycline structure
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Common Name | Calcium oxytetracycline | ||
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| CAS Number | 7179-50-2 | Molecular Weight | 498.49600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H22CaN2O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Calcium oxytetracyclineOxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity[1][2][3]. |
| Name | calcium,(5S,5aR,6S,6aR,7S,10aR)-9-carbamoyl-7-(dimethylamino)-5,6,10,10a-tetrahydroxy-5-methyl-8,11-dioxo-5a,6,6a,7-tetrahydrotetracene-1,12-diolate |
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| Synonym | More Synonyms |
| Description | Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity[1][2][3]. |
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| Related Catalog | |
| In Vitro | Oxytetracycline calcium is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline calcium is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2]. |
| In Vivo | The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) calcium for 10 days are species specific. Oxytetracycline calcium increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1]. For Oxytetracycline calcium, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline calcium is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1]. |
| References |
[2]. Pickens LB, et al. Oxytetracycline biosynthesis. J Biol Chem. 2010 Sep 3;285(36):27509-15. |
| Molecular Formula | C22H22CaN2O9 |
|---|---|
| Molecular Weight | 498.49600 |
| Exact Mass | 498.09500 |
| PSA | 208.50000 |
| LogP | 0.06020 |
| InChIKey | QMRSMEWUOGCGKH-IFLJXUKPSA-N |
| SMILES | CN(C)C1C(=O)C(C(N)=O)=C(O)C2(O)C(=O)C3=C(O)c4c(O)cccc4C(C)(O)C3C(O)C12.[Ca] |
| C22H22N2O9.Ca |
| Oxytetracycline calcium |
| Calcium oxytetracycline |
| EINECS 230-540-4 |
| 5 Oxytetracycline calcium |
| Oxytetracycline,Calcium (1:1) Salt |