Ilimaquinone

Modify Date: 2024-01-10 07:51:07

Ilimaquinone structure	Common Name	Ilimaquinone
	CAS Number	71678-03-0	Molecular Weight	358.471
	Density	1.1±0.1 g/cm3	Boiling Point	478.4±45.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₃₀O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	159.9±22.2 °C

Use of Ilimaquinone

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects[2].

Name	3-[[(1R,2S,4aS,8aS)-1,2,4a-trimethyl-5-methylidene-3,4,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]methyl]-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
Synonym	More Synonyms

Description	Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI50s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively[1]. Cell Viability Assay[1] Cell Line: Prostate cancer PC-3 cells Concentration: 0.3, 1, 3, 10, and 30 μM Incubation Time: 48 hours Result: Inhibited the proliferation of PC-3 cells in a concentration-dependent manner.
In Vivo	Ilimaquinone exhibits terminal elimination half-lives (T1/2=1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats[2].
References	[1]. Pin-Hsuan Lu, et al. Ilimaquinone, a Marine Sponge Metabolite, Displays Anticancer Activity via GADD153-mediated Pathway. Eur J Pharmacol. 2007 Feb 5;556(1-3):45-54. [2]. Heebin Son, et al. Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted From a Marine Sponge in Rats. Mar Drugs. 2019 Mar 17;17(3):171.

Density	1.1±0.1 g/cm3
Boiling Point	478.4±45.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₀O₄
Molecular Weight	358.471
Flash Point	159.9±22.2 °C
Exact Mass	358.214417
PSA	63.60000
LogP	6.38
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.549

Ilimaquinone MSDS(Chinese)

WGK Germany	3

Precursor 8
CAS#:121994-56-7 3-[[(1R,2S,4aS,... CAS#:41722-49-0 (8aS)-5,8a-dime... CAS#:2441-46-5 Benzene,1,2,4,5... CAS#:86489-89-6 3-(Bromomethyl)...
CAS#:213026-15-4 (1R,4aS)-trans-... CAS#:213026-18-7 (1R,2S,4aS)-tra... CAS#:583-63-1 2-benzoquinone CAS#:3117-03-1 2,5-dimethoxycy...
DownStream 1
CAS#:121994-56-7 3-[[(1R,2S,4aS,...