CL-216942

Modify Date: 2024-01-13 13:26:18

CL-216942 structure	Common Name	CL-216942
	CAS Number	71439-68-4	Molecular Weight	434.92500
	Density	N/A	Boiling Point	646.3ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₃ClN₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	344.7ºC

Use of CL-216942

Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4].

Name	9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone], dihydrochloride
Synonym	More Synonyms

Description	Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase[1]
In Vitro	Bisantrene dihydrochloride promots DNase I cleavage at oligopurine-oligopyrimidine tracts and slightly reduces the cleavage activity at alternating purine-pyrimidine sequences[1]. Bisantrene dihydrochloride is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA[2].
In Vivo	Bisantrene dihydrochloride is an antitumor agent active against a number of experimental tumors, including P388 leukemia, L1210 leukemia, Lieberman plasma cell tumor, B16 melanoma, colon tumor 26, and Ridgway osteogenic sarcoma[3]. Bisantrene dihydrochloride is effective over a dose range of 1.56 to 150 mg/kg depending upon the frequency, route, and schedule of the treatment and the tumor model used[3]. Bisantrene dihydrochloride (25, 50 and 100 mg/kg; i.p.; once) pretreats with macrophages shows antitumor effect to mice with P815 tumor cells injection[3]. Bisantrene dihydrochloride (10-150 mg/kg; i.v.; once) dose-dependently induces leukopenia in Neo mice. B cells and macrophages are targets for bisantrene dihydrochloride toxicity[4].

Boiling Point	646.3ºC at 760 mmHg
Molecular Formula	C₂₂H₂₃ClN₈
Molecular Weight	434.92500
Flash Point	344.7ºC
Exact Mass	434.17300
PSA	97.56000
LogP	2.87100

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CA9647000

CHEMICAL NAME :: 9,10-Anthracenedicarboxaldehyde, bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone), dihydrochloride

CAS REGISTRY NUMBER :: 71439-68-4

LAST UPDATED :: 198506

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H22-N8.2Cl-H

MOLECULAR WEIGHT :: 471.44

WISWESSER LINE NOTATION :: L C666J B1UNM- BT5M CN BUTJ& I1UNM- BT5M CN BUTJ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,440,1982

9,10-anthracenedicarboxaldehyde bis<(4,5-dihydro-1H-imidazol-2-yl)hydrazone> dihydrochloride

Bisantrene hydrochloride

Bisantrene dihydrochloride

9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone) dihydrochloride

DC Chemicals Limited
China
Product Name: CL-216942
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Bisantrene dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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