CL-216942
Modify Date: 2024-01-13 13:26:18
CL-216942 structure
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Common Name | CL-216942 | ||
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| CAS Number | 71439-68-4 | Molecular Weight | 434.92500 | |
| Density | N/A | Boiling Point | 646.3ºC at 760 mmHg | |
| Molecular Formula | C22H23ClN8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 344.7ºC | |
Use of CL-216942Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4]. |
| Name | 9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone], dihydrochloride |
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| Synonym | More Synonyms |
| Description | Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4]. |
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| Related Catalog | |
| Target |
Topoisomerase[1] |
| In Vitro | Bisantrene dihydrochloride promots DNase I cleavage at oligopurine-oligopyrimidine tracts and slightly reduces the cleavage activity at alternating purine-pyrimidine sequences[1]. Bisantrene dihydrochloride is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA[2]. |
| In Vivo | Bisantrene dihydrochloride is an antitumor agent active against a number of experimental tumors, including P388 leukemia, L1210 leukemia, Lieberman plasma cell tumor, B16 melanoma, colon tumor 26, and Ridgway osteogenic sarcoma[3]. Bisantrene dihydrochloride is effective over a dose range of 1.56 to 150 mg/kg depending upon the frequency, route, and schedule of the treatment and the tumor model used[3]. Bisantrene dihydrochloride (25, 50 and 100 mg/kg; i.p.; once) pretreats with macrophages shows antitumor effect to mice with P815 tumor cells injection[3]. Bisantrene dihydrochloride (10-150 mg/kg; i.v.; once) dose-dependently induces leukopenia in Neo mice. B cells and macrophages are targets for bisantrene dihydrochloride toxicity[4]. |
| Boiling Point | 646.3ºC at 760 mmHg |
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| Molecular Formula | C22H23ClN8 |
| Molecular Weight | 434.92500 |
| Flash Point | 344.7ºC |
| Exact Mass | 434.17300 |
| PSA | 97.56000 |
| LogP | 2.87100 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| 9,10-anthracenedicarboxaldehyde bis<(4,5-dihydro-1H-imidazol-2-yl)hydrazone> dihydrochloride |
| Bisantrene hydrochloride |
| Bisantrene dihydrochloride |
| 9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone) dihydrochloride |