Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)

Modify Date: 2024-01-07 19:04:57

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) Structure
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) structure
Common Name Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)
CAS Number 71138-97-1 Molecular Weight 286.28
Density N/A Boiling Point N/A
Molecular Formula C10H22O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)


Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility drugs. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg[1].

 Names

Name HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE

  Biological Activity

Description Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility drugs. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg[1].
Related Catalog
In Vivo Hydroxypropylmethyl cellulose acetate succinate(2.5 g/kg;p.o.;单剂量)在大鼠无显著急性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate(0.63、1.25、2.5 g/kg;p.o.;每日一次,连续 2 个月,每周 6 天)在大鼠无显著亚慢性毒性[1]。 Hydroxypropylmethyl cellulose acetate succinate(1.25 g/kg、2.5 g/kg;口服;每天一次,连续 2 个月,每周 6 天)在大鼠无显著慢性毒性[1]。
References

[1]. Hoshi N, et al. Toxicological studies of hydroxypropylmethylcellulose acetate succinate--acute toxicity in rats and rabbits, and subchronic and chronic toxicities in rats. J Toxicol Sci. 1985 Oct;10 Suppl 2:147-85.  

 Chemical & Physical Properties

Molecular Formula C10H22O9
Molecular Weight 286.28
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