Bucindolol

Modify Date: 2024-01-04 17:11:20

Bucindolol structure	Common Name	Bucindolol
	CAS Number	71119-11-4	Molecular Weight	363.453
	Density	1.2±0.1 g/cm3	Boiling Point	605.3±55.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₅N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	319.9±31.5 °C

Use of Bucindolol

Bucindolol is a β1-adrenergic receptor blocker, with intrinsic sympathomimetic activity, used in the research of heart failure[1].

Name	2-[2-hydroxy-3-[[1-(1H-indol-3-yl)-2-methylpropan-2-yl]amino]propoxy]benzonitrile
Synonym	More Synonyms

Description	Bucindolol is a β1-adrenergic receptor blocker, with intrinsic sympathomimetic activity, used in the research of heart failure[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
References	[1]. Liggett SB, et al. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11288-93.

Density	1.2±0.1 g/cm3
Boiling Point	605.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₅N₃O₂
Molecular Weight	363.453
Flash Point	319.9±31.5 °C
Exact Mass	363.194672
PSA	81.07000
LogP	3.19
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.632

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI4637550

CHEMICAL NAME :: Benzonitrile, 2-(2-hydroxy-3-((2-(1H-indol-3-yl)-1,1-dimethylethyl) amino)propoxy)-

CAS REGISTRY NUMBER :: 71119-11-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H25-N3-O2

MOLECULAR WEIGHT :: 363.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0065295

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0065295

2-Cyanophenol

CAS#:611-20-1

Bucindolol

CAS#:71119-11-4

Literature: Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289

Gramine

CAS#:87-52-5

Bucindolol

CAS#:71119-11-4

Literature: Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289

3-(2-METHYL-2-N...

CAS#:835-40-5

Bucindolol

CAS#:71119-11-4

Literature: Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289

2-(3-chloro-2-h...

CAS#:42864-99-3

Bucindolol

CAS#:71119-11-4

Literature: Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289

(5R)-5-Phenylmo...

CAS#:304-53-0

2-glycidyloxybe...

CAS#:38465-16-6

Bucindolol

CAS#:71119-11-4

Literature: Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289

Precursor 6
CAS#:611-20-1 2-Cyanophenol CAS#:87-52-5 Gramine CAS#:835-40-5 3-(2-METHYL-2-N... CAS#:42864-99-3 2-(3-chloro-2-h...
CAS#:304-53-0 (5R)-5-Phenylmo... CAS#:38465-16-6 2-glycidyloxybe...
DownStream 0

Benzonitrile, 2-[2-hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]-

2-(2-Hydroxy-3-{[1-(1H-indol-3-yl)-2-methylpropan-2-yl]amino}propoxy)benzonitrile

Bucindolol

2-(2-Hydroxy-3-{[1-(1H-indol-3-yl)-2-methyl-2-propanyl]amino}propoxy)benzonitrile

2-[2-Hydroxy-3-[[2-(1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile

o-(2-Hydroxy-3-((2-indol-3-yl-1,1-dimethylethyl)amino)propoxy)benzonitrile

Bucindolol

Use of Bucindolol

Names

Bucindolol Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synthetic Route

Precursor & DownStream

Synonyms