e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Antihypertensive indole derivatives of phenoxypropanolamines with. beta.-adrenergic receptor antagonist and vasodilating activity

…, JL Minielli, D Deitchman, JL Perhach Jr…

Index: Kreighbaum; Matier; Dennis; Minielli; Deitchman; Perhach Jr.; Comer Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 285 - 289

Full Text: HTML

Citation Number: 33

Abstract

A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl [ie, l, l-dimethyl-2- (1H-indol-3-yl) ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR),@-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by ...

1-chloro-3-(2-cyclohexyl-phenoxy)-propan-2-ol Structure

1-chloro-3-(2-c...

~%

2-[(2-cyclohexylphenoxy)methyl]oxirane Structure

2-[(2-cyclohexy...

2-CYCLOHEXYLPHENOL Structure

2-CYCLOHEXYLPHENOL

~%

2-[(2-cyclohexylphenoxy)methyl]oxirane Structure

2-[(2-cyclohexy...

1-chloro-3-(2,3-dimethylphenoxy)propan-2-ol Structure

1-chloro-3-(2,3...

~%

2-[(2,3-dimethylphenoxy)methyl]oxirane Structure

2-[(2,3-dimethy...

2,3-Dimethylphenol Structure

2,3-Dimethylphenol

~%

2-[(2,3-dimethylphenoxy)methyl]oxirane Structure

2-[(2,3-dimethy...

5-methoxy-3-(2,2-dimethyl-2-nitroethyl)-1H-indole Structure

5-methoxy-3-(2,...

~96%

1-(2-methylphenyl)-2,4-dioxopyrimidine-5-carbonitrile Structure

1-(2-methylphen...

5-METHOXYGRAMINE Structure

5-METHOXYGRAMINE

~%

1-(2-methylphenyl)-2,4-dioxopyrimidine-5-carbonitrile Structure

1-(2-methylphen...

1-chloro-3-(4-chloro-2-methyl-phenoxy)-propan-2-ol Structure

1-chloro-3-(4-c...

~%

Oxirane,2-[(4-chloro-2-methylphenoxy)methyl]- Structure

Oxirane,2-[(4-c...

4-Chloro-2-methylphenol Structure

4-Chloro-2-meth...

~%

Oxirane,2-[(4-chloro-2-methylphenoxy)methyl]- Structure

Oxirane,2-[(4-c...

2-(Trifluoromethyl)phenol Structure

2-(Trifluoromet...

~%

2-((2-(TRIFLUOROMETHYL)PHENOXY)METHYL)OXIRANE Structure

2-((2-(TRIFLUOR...

2-(3-chloro-2-hydroxypropoxy)benzonitrile Structure

2-(3-chloro-2-h...

~%

2-glycidyloxybenzonitrile Structure

2-glycidyloxybe...

2-Cyanophenol Structure

~%

2-glycidyloxybenzonitrile Structure

2-glycidyloxybe...

2-Cyanophenol Structure

Epichlorohydrin Structure

Epichlorohydrin

~%

2-(3-chloro-2-hydroxypropoxy)benzonitrile Structure

2-(3-chloro-2-h...

2-Cyanophenol Structure

~%

Bucindolol Structure

Gramine Structure

~%

Bucindolol Structure

3-(2-METHYL-2-NITROPROPYL)INDOLE Structure

3-(2-METHYL-2-N...

~%

Bucindolol Structure

2-(3-chloro-2-hydroxypropoxy)benzonitrile Structure

2-(3-chloro-2-h...

~%

Bucindolol Structure

(5R)-5-Phenylmorpholin-3-one Structure

(5R)-5-Phenylmo...

2-glycidyloxybenzonitrile Structure

2-glycidyloxybe...

~%

Bucindolol Structure

1-(2-allyl-phenoxy)-3-chloro-propan-2-ol Structure

1-(2-allyl-phen...

~%

2-[(2-prop-2-enylphenoxy)methyl]oxirane Structure

2-[(2-prop-2-en...

2-Allylphenol Structure

~%

2-[(2-prop-2-enylphenoxy)methyl]oxirane Structure

2-[(2-prop-2-en...

5-bromo-3-(2,2-dimethyl-2-nitroethyl)-1H-indole Structure

5-bromo-3-(2,2-...

~97%

1-(5-bromo-1H-indol-3-yl)-2-methylpropan-2-amine Structure

1-(5-bromo-1H-i...

5-Bromogramine Structure

~%

1-(5-bromo-1H-indol-3-yl)-2-methylpropan-2-amine Structure

1-(5-bromo-1H-i...

1-Chlor-2-hydroxy-3-o-fluorphenoxypropan Structure

1-Chlor-2-hydro...

~%

Oxirane,2-[(2-fluorophenoxy)methyl]- Structure

Oxirane,2-[(2-f...

2-Fluorophenol Structure

~%

Oxirane,2-[(2-fluorophenoxy)methyl]- Structure

Oxirane,2-[(2-f...

1-chloro-3-(2,4-dimethylphenoxy)propan-2-ol Structure

1-chloro-3-(2,4...

~%

2-[(2,4-Dimethylphenoxy)methyl]oxirane Structure

2-[(2,4-Dimethy...

2,4-xylenol Structure

~%

2-[(2,4-Dimethylphenoxy)methyl]oxirane Structure

2-[(2,4-Dimethy...