Vorapaxar sulfate
Modify Date: 2024-01-02 16:40:50
Vorapaxar sulfate structure
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Common Name | Vorapaxar sulfate | ||
|---|---|---|---|---|
| CAS Number | 705260-08-8 | Molecular Weight | 590.660 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H35FN2O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Vorapaxar sulfateVorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner[1]. |
| Name | vorapaxar sulfate |
|---|---|
| Synonym | More Synonyms |
| Description | Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner[1]. |
|---|---|
| Target |
Ki: 8.1 nM (PAR-1)[1] |
| In Vitro | Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM[1]. |
| References |
| Molecular Formula | C29H35FN2O8S |
|---|---|
| Molecular Weight | 590.660 |
| Exact Mass | 590.209839 |
| PSA | 163.99000 |
| LogP | 6.26190 |
| Storage condition | -20℃ |
| Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate sulfate (1:1) |
| vorapaxar monosulfate |
| Vorapaxar Sulfate |
| Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester, sulfate (1:1) |
| UNII-IN66038E6C |
| ethyl N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-1H-benzo[f][2]benzofuran-6-yl]carbamate,sulfuric acid |
| Zontivity |
| SCH 530348 |