5-Fluoroorotic acid

Modify Date: 2024-01-02 08:40:04

5-Fluoroorotic acid structure	Common Name	5-Fluoroorotic acid
	CAS Number	703-95-7	Molecular Weight	174.087
	Density	1.8±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₅H₃FN₂O₄	Melting Point	278 °C (dec.)(lit.)
	MSDS	Chinese	Flash Point	N/A

Use of 5-Fluoroorotic acid

5-Fluoroorotic is a selective agent in yeast molecular genetics. 5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects[1][2].

Name	5-Fluoroorotic Acid
Synonym	More Synonyms

Description	5-Fluoroorotic is a selective agent in yeast molecular genetics. 5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Boeke JD, et, al. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 1987; 154: 164-75. [2]. Nikolova K, et, al. Studies on the antimycotic activity of 5-fluoroorotic acid. Methods Find Exp Clin Pharmacol. 1987 Feb; 9(2): 85-9.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

References

[1]. Boeke JD, et, al. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 1987; 154: 164-75.

[2]. Nikolova K, et, al. Studies on the antimycotic activity of 5-fluoroorotic acid. Methods Find Exp Clin Pharmacol. 1987 Feb; 9(2): 85-9.

Density	1.8±0.1 g/cm3
Melting Point	278 °C (dec.)(lit.)
Molecular Formula	C₅H₃FN₂O₄
Molecular Weight	174.087
Exact Mass	174.007690
PSA	103.02000
LogP	-1.00
Index of Refraction	1.580
Storage condition	−20°C
Water Solubility	NH4OH 4 M: 50 mg/mL, clear, faintly yellow

5-Fluoroorotic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV7800000

CHEMICAL NAME :: 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-

CAS REGISTRY NUMBER :: 703-95-7

LAST UPDATED :: 198605

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H3-F-N2-O4

MOLECULAR WEIGHT :: 174.10

WISWESSER LINE NOTATION :: T6VMVMJ EVQ FF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 981 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
RTECS	UV7800000
HS Code	2933599090

Precursor 2
CAS#:721-33-5 2-ethylsulfanyl... CAS#:717-48-6 5-fluoro-2-meth...
DownStream 1
CAS#:51-21-8 Fluorouracil

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

EINECS 211-876-0

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5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid

MFCD00042526

5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid

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5-Fluoroorotic acid

5-Fluoroorotic acid monohydrate

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 5-Fluoroorotic acid
Price: ￥228.0/1g ￥808.0/5g
Purity: 99.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 5-Fluoroorotic acid
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Fluoroorotic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 5-Fluoroorotic acid
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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