Benzenesulfonamide,4-bromo-N-methyl-

Modify Date: 2024-01-29 16:52:07

Benzenesulfonamide,4-bromo-N-methyl- Structure
Benzenesulfonamide,4-bromo-N-methyl- structure
Common Name Benzenesulfonamide,4-bromo-N-methyl-
CAS Number 703-12-8 Molecular Weight 250.11300
Density 1.601g/cm3 Boiling Point 330.3ºC at 760 mmHg
Molecular Formula C7H8BrNO2S Melting Point 70-72ºC
MSDS USA Flash Point 153.6ºC

 Names

Name 4-Bromo-N-methylbenzenesulfonamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.601g/cm3
Boiling Point 330.3ºC at 760 mmHg
Melting Point 70-72ºC
Molecular Formula C7H8BrNO2S
Molecular Weight 250.11300
Flash Point 153.6ºC
Exact Mass 248.94600
PSA 54.55000
LogP 2.82890
Index of Refraction 1.574

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: N-Methyl 4-bromobenzenesulfonamide
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:N-Methyl 4-bromobenzenesulfonamide
CAS number:703-12-8

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C7H8BrNO2S
Molecular weight:250.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide, sulfur oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB0960000
CHEMICAL NAME :
Benzenesulfonamide, p-bromo-N-methyl-
CAS REGISTRY NUMBER :
703-12-8
BEILSTEIN REFERENCE NO. :
3261758
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H8-Br-N-O2-S
MOLECULAR WEIGHT :
250.13
WISWESSER LINE NOTATION :
ER DSWM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
562 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,548,1965

 Safety Information

Hazard Codes Xi
Risk Phrases 22
HS Code 2935009090

 Synthetic Route

~99%

Benzenesulfonamide,4-bromo-N-methyl- Structure

Benzenesulfonam...

CAS#:703-12-8

Literature: Richardson, Christine M.; Nunns, Claire L.; Williamson, Douglas S.; Parratt, Martin J.; Dokurno, Pawel; Howes, Rob; Borgognoni, Jenifer; Drysdale, Martin J.; Finch, Harry; Hubbard, Roderick E.; Jackson, Philip S.; Kierstan, Peter; Lentzen, Georg; Moore, Jonathan D.; Murray, James B.; Simmonite, Heather; Surgenor, Allan E.; Torrance, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 3880 - 3885

~%

Benzenesulfonamide,4-bromo-N-methyl- Structure

Benzenesulfonam...

CAS#:703-12-8

Literature: Journal of the American Chemical Society, , vol. 45, p. 2697

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Benzenesulfonamide,4-bromo-N-methyl- Structure

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CAS#:703-12-8

Literature: US5380721 A1, ;

~82%

Benzenesulfonamide,4-bromo-N-methyl- Structure

Benzenesulfonam...

CAS#:703-12-8

Literature: Maclean, Derek; Hale, Ron; Chen, Mingying Organic Letters, 2001 , vol. 3, # 19 p. 2977 - 2980

~%

Benzenesulfonamide,4-bromo-N-methyl- Structure

Benzenesulfonam...

CAS#:703-12-8

Literature: Synthetic Communications, , vol. 19, # 9-10 p. 1499 - 1504

~%

Benzenesulfonamide,4-bromo-N-methyl- Structure

Benzenesulfonam...

CAS#:703-12-8

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 19, # 4 p. 671 - 675 Zhurnal Organicheskoi Khimii, , vol. 19, # 4 p. 761 - 766

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Synonyms

p-Bromo-N-methylbenzenesulfonamide
Benzenesulfonamide,4-bromo-N-methyl
Benzenesulfonamide,p-bromo-N-methyl
4-bromo-N-methyl benzenesulfonamide
N-METHYL 4-BROMOBENZENESULFONAMIDE
4-Bromo-N-methylbenzenesulphonamide
4-bromo-benzenesulfonic acid methylamide
4-Brom-benzolsulfonsaeure-methylamid