Dihydroavermectin B1b

Modify Date: 2025-09-20 20:19:25

Dihydroavermectin B1b structure	Common Name	Dihydroavermectin B1b
	CAS Number	70209-81-3	Molecular Weight	861.06600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₇H₇₂O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dihydroavermectin B1b

Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].

Name	22,23-dihydroavermectin B1b
Synonym	More Synonyms

Description	Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
In Vitro	Ivermectin and Ivermectin B1b are the most potent inhibitors of contraction and motility in both susceptible isolates (H. contortus McMaster and and O. circumcincta McMaster) also show the highest resistance ratios in both species[3]. Vermectin is a macrocyclic lactone that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs) but has no modulatory activity on 5-HT3 receptors[4].
In Vivo	Ivermectin B1b causes snail death[1].
References	[1]. Katz N, et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. J Antibiot (Tokyo). 2017;70(5):680-684. [2]. Bray M, et al. Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. Antiviral Res. 2020;178:104805. [3]. Demeler J, et al. Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. Parasitology. 2014;141(7):948-956. [4]. Collins T, et al. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. 2010;78(2):198-204.

Molecular Formula	C₄₇H₇₂O₁₄
Molecular Weight	861.06600
Exact Mass	860.49200
PSA	170.06000
LogP	5.21130
InChIKey	VARHUCVRRNANBD-AGNWDZAWSA-N
SMILES	COC1CC(OC2C(C)OC(OC3C(C)=CCC4CC(CC5(CCC(C)C(C(C)C)O5)O4)OC(=O)C4C=C(C)C(O)C5OCC(=CC=CC3C)C45O)CC2OC)OC(C)C1O

RIDADR	UN 2588

ivermectin B1b

IVERMECTIN B1B (DIHYDROAVERMECTIN B1B, 22, 23-DIHYDROAVERMECTIN B1B )

DIHYDROAVERMECTIN B1B

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dihydroavermectin B1b
Price: Check
Purity: 95.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Ivermectin B1b
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.