Ivermectin B1a

Modify Date: 2024-01-04 20:22:35

Ivermectin B1a Structure
Ivermectin B1a structure
Common Name Ivermectin B1a
CAS Number 71827-03-7 Molecular Weight 875.09300
Density N/A Boiling Point N/A
Molecular Formula C48H74O14 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ivermectin B1a


Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310)[1]. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[2].

 Names

Name 22,23-dihydroavermectin B1a
Synonym More Synonyms

 Ivermectin B1a Biological Activity

Description Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310)[1]. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19[2].
Related Catalog
In Vitro Ivermectin belongs to the macrocyclic lactone class of avermectins and consists of a mixture of two homologous compounds, ivermectin B1a (not less than 80%) and ivermectin B1b (not more than 20%). Ivermectin B1a, the major component of Ivermectin, is inactive at a concentration of 0.3 μg/ml, whereas in the case of the minor component, ivermectin B1b, the same concentration produces 100% mortality of snails[1].
References

[1]. Naftale Kat, et al. Ivermectin Efficacy Against Biomphalaria, Intermediate Host Snail Vectors of Schistosomiasis. J Antibiot (Tokyo). 2017 May;70(5):680-684.

[2]. Khan Sharun, et al. Ivermectin, a New Candidate Therapeutic Against SARS-CoV-2/COVID-19. Ann Clin Microbiol Antimicrob. 2020 May 30;19(1):23.

 Chemical & Physical Properties

Molecular Formula C48H74O14
Molecular Weight 875.09300
Exact Mass 874.50800
PSA 170.06000
LogP 5.60140

 Synonyms

Prestwick_516
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