Pimonidazole hydrochloride

Modify Date: 2024-01-10 11:25:11

Pimonidazole hydrochloride structure	Common Name	Pimonidazole hydrochloride
	CAS Number	70132-51-3	Molecular Weight	290.74700
	Density	N/A	Boiling Point	490.5ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₉ClN₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	250.5ºC

Use of Pimonidazole hydrochloride

Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].

Name	1-(2-nitroimidazol-1-yl)-3-piperidin-1-ylpropan-2-ol,hydrochloride
Synonym	More Synonyms

Description	Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7. [2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7.

[2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.

Boiling Point	490.5ºC at 760 mmHg
Molecular Formula	C₁₁H₁₉ClN₄O₃
Molecular Weight	290.74700
Flash Point	250.5ºC
Exact Mass	290.11500
PSA	87.11000
LogP	1.90120

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM9465000

CHEMICAL NAME :: 1-Piperidineethanol, alpha-((2-nitro-1H-imidazol-1-yl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 70132-51-3

LAST UPDATED :: 198709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H18-N4-O3.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IOBPD3 International Journal of Radiation Oncology, Biology, Physics. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1975- Volume(issue)/page/year: 12,1097,1986

Ro 03-8799

Pimonidazole hydrochloride

1-(2-nitro-1h-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol hydrochloride(1:1)

Pimonidazole HCl

DC Chemicals Limited
China
Product Name: Ro 03-8799
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Piperidineethanol, alpha-((2-nitro-1H-imidazol-1-yl)methyl)-, monohydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Pimonidazole hydrochloride

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