GO289
Modify Date: 2025-08-27 15:01:40
GO289 structure
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Common Name | GO289 | ||
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| CAS Number | 694522-87-7 | Molecular Weight | 419.297 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H15BrN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GO289GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro; GO289 showed only a moderate or minor effect on the activity of 59 kinases from a variety of classes, the second most affected kinase was PIM2 with an IC50 of 13 nM; caused dose-dependent lengthening of circadian period not only in Bmal1-dLuc reporter cells but also in Per2-dLuc reporter cells with a phase opposite to that of Bmal1-dLuc, inhibits phosphorylation of clock protein PER2 S693 in cells; strongly inhibits Caki-2, A498, and 769-P cancer cells, significantly reduces growth of mouse MLL-AF9 leukemia cells without effect on hematopoietic progenitor cells; shows effectivity on circadian period and reporter signal intensity in spleen explants of MLL-AF9 mice. |
| Name | GO289 |
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| Description | GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro; GO289 showed only a moderate or minor effect on the activity of 59 kinases from a variety of classes, the second most affected kinase was PIM2 with an IC50 of 13 nM; caused dose-dependent lengthening of circadian period not only in Bmal1-dLuc reporter cells but also in Per2-dLuc reporter cells with a phase opposite to that of Bmal1-dLuc, inhibits phosphorylation of clock protein PER2 S693 in cells; strongly inhibits Caki-2, A498, and 769-P cancer cells, significantly reduces growth of mouse MLL-AF9 leukemia cells without effect on hematopoietic progenitor cells; shows effectivity on circadian period and reporter signal intensity in spleen explants of MLL-AF9 mice. |
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| References | References 1. Tsuyoshi Oshima, et al. Science Advances 23 Jan 2019: Vol. 5, no. 1, eaau9060. DOI: 10.1126/sciadv.aau9060. View Related Products by Target Casein Kinase |
| Molecular Formula | C17H15BrN4O2S |
|---|---|
| Molecular Weight | 419.297 |
| InChIKey | DARDDBZKGVEVKB-VXLYETTFSA-N |
| SMILES | COc1cc(C=Nn2c(SC)nnc2-c2ccccc2)c(Br)cc1O |
| Hazard Codes | Xi |
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