5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide
Modify Date: 2025-08-23 18:01:52
5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide structure
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Common Name | 5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide | ||
|---|---|---|---|---|
| CAS Number | 68377-92-4 | Molecular Weight | 371.541 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 599.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H21N3O2S3 | Melting Point | 148-149ºC | |
| MSDS | N/A | Flash Point | 316.6±32.9 °C | |
Use of 5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamideArotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases[1]. |
| Name | 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases[1]. |
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| Related Catalog | |
| Target |
IC50: α/β-adrenergic receptor |
| In Vivo | Arotinolol (oral gavage; 200 mg/kg; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mouse[1]. Animal Model: SHR mice[1] Dosage: 200 mg/kg Administration: Orally gavage; 200 mg/kg; once daily; 8 weeks Result: Improved arterial stiffness in SHR. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 599.8±60.0 °C at 760 mmHg |
| Melting Point | 148-149ºC |
| Molecular Formula | C15H21N3O2S3 |
| Molecular Weight | 371.541 |
| Flash Point | 316.6±32.9 °C |
| Exact Mass | 371.079590 |
| PSA | 170.02000 |
| LogP | 2.67 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.646 |
| InChIKey | BHIAIPWSVYSKJS-UHFFFAOYSA-N |
| SMILES | CC(C)(C)NCC(O)CSc1nc(-c2ccc(C(N)=O)s2)cs1 |
| Storage condition | 2-8°C |
| Hazard Codes | Xi |
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5-(2-((3-(tert-... CAS#:68377-92-4 |
| Literature: US3932400 A1, ; US 3932400 A |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| Arotinolo |
| 5-(2-{[3-(tert-Butylamino)-2-hydroxypropyl]sulfanyl}-1,3-thiazol-4-yl)thiophene-2-carboxamide |
| 5-[2-({2-Hydroxy-3-[(2-methyl-2-propanyl)amino]propyl}sulfanyl)-1,3-thiazol-4-yl]-2-thiophenecarboxamide |
| Arottnolol |
| Arotinolol |
| UNII:394E3P3B99 |
| 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]- |
| (±)-5-[2-[[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-2-thiophenecarboxamide |
| ARL |
| 2-(3'-tert-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole |
| 5-[2-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}thio)-1,3-thiazol-4-yl]thiophene-2-carboxamide |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide
- Price: ￥808.0/50mg ￥2408.0/250mg
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Arotinolol
- Price: $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Arotinolol
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Shanghai Amole Biotechnology Co., Ltd.
- China
- Product Name: 5-(2-((3-(tert-Butylamino)-2-hydroxypropyl)thio)thiazol-4-yl)thiophene-2-carboxamide
- Price: ￥Inquiry/100mg ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/25mg
- Purity: 95.0%
- Delivery: Inquiry
- Contact: Xiyao Wang
- Email: 3623107365@qq.com
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Price: ￥1444.8/250mg
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