6,8-diprenylnaringenin

Modify Date: 2024-01-04 00:39:10

6,8-diprenylnaringenin structure	Common Name	6,8-diprenylnaringenin
	CAS Number	68236-11-3	Molecular Weight	408.48700
	Density	1.22g/cm3	Boiling Point	639.245°C at 760 mmHg
	Molecular Formula	C₂₅H₂₈O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	218.297°C

Use of 6,8-diprenylnaringenin

6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].

Name	6,8-diprenylnaringenin
Synonym	More Synonyms

Description	6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP
References	[1]. Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110. [2]. Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Metabolic Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP

References

[1]. Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110.

[2]. Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5.

Density	1.22g/cm3
Boiling Point	639.245°C at 760 mmHg
Molecular Formula	C₂₅H₂₈O₅
Molecular Weight	408.48700
Flash Point	218.297°C
Exact Mass	408.19400
PSA	86.99000
LogP	5.52730

Senegalensien

Lonchocarpol A

(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one

Senegalensein

Senegalensin

4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methyl-2-butenyl)-,(S)

6,8-Diprenylnaringenin

BioBioPha
China
Product Name: 6,8-diprenylnaringenin
Price: ￥3400.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

DC Chemicals Limited
China
Product Name: 6,8-Diprenylnaringenin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: senegalensin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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