68236-11-3

68236-11-3 structure

Name: 6,8-diprenylnaringenin
Chemical Name: 6,8-diprenylnaringenin
CAS Number: 68236-11-3
Molecular Formula: C₂₅H₂₈O₅
Molecular Weight: 408.48700
Catalog: Signaling Pathways Membrane Transporter/Ion Channel BCRP
Create Date: 2017-05-06 22:55:16
Modify Date: 2024-01-04 00:39:10
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].

Name	6,8-diprenylnaringenin
Synonyms	Senegalensien Lonchocarpol A (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one Senegalensein Senegalensin 4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methyl-2-butenyl)-,(S) 6,8-Diprenylnaringenin

Description	6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP
References	[1]. Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110. [2]. Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5.