N-Butanoyl-L-homoserine lactone

Modify Date: 2024-01-05 09:18:00

N-Butanoyl-L-homoserine lactone Structure
N-Butanoyl-L-homoserine lactone structure
Common Name N-Butanoyl-L-homoserine lactone
CAS Number 67605-85-0 Molecular Weight 171.194
Density 1.1±0.1 g/cm3 Boiling Point 428.1±34.0 °C at 760 mmHg
Molecular Formula C8H13NO3 Melting Point N/A
MSDS N/A Flash Point 212.7±25.7 °C

 Use of N-Butanoyl-L-homoserine lactone


N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1].

 Names

Name N-[(3S)-2-oxooxolan-3-yl]butanamide
Synonym More Synonyms

 N-Butanoyl-L-homoserine lactone Biological Activity

Description N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 428.1±34.0 °C at 760 mmHg
Molecular Formula C8H13NO3
Molecular Weight 171.194
Flash Point 212.7±25.7 °C
Exact Mass 171.089539
PSA 55.40000
LogP -1.10
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.476
Storage condition 2-8°C

 Synthetic Route

~%

N-Butanoyl-L-homoserine lactone Structure

N-Butanoyl-L-ho...

CAS#:67605-85-0

Literature: Nippon Kagaku Zasshi, , vol. 79, p. 81,83 Chem.Abstr., , p. 5448

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

C4-homoserine lactone
Butanamide, N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
N-Butyryl-DL-homoserin-lacton
HL4
N-Butyryl-L-homoserine lactone
N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide
(+)-a(S)-butyr-amido-r-butyrolactone
N-[(3S)-2-Oxotetrahydro-3-furanyl]butanamide
butanoyl homoserine lactone