5-Iminodaunorubicin

Modify Date: 2024-01-09 12:51:10

5-Iminodaunorubicin structure	Common Name	5-Iminodaunorubicin
	CAS Number	67324-99-6	Molecular Weight	562.99600
	Density	1.51g/cm3	Boiling Point	864.9ºC at 760 mmHg
	Molecular Formula	C₂₇H₃₁ClN₂O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	476.9ºC

Use of 5-Iminodaunorubicin

5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].

Name	12-Iminodaunorubicin HCl
Synonym	More Synonyms

Description	5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	In mouse leukemia L1210 cells, 5-Iminodaunorubicin produces protein-concealed DNA strand breaks. Many of the 5-iminodaunorubicin breaks may arise from apposed single-strand breaks (i.e., double-strand breaks)[2].
In Vivo	In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic[1].
References	[1]. R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44(9):4030-9. [2]. L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42(7):2687-91.

Density	1.51g/cm3
Boiling Point	864.9ºC at 760 mmHg
Molecular Formula	C₂₇H₃₁ClN₂O₉
Molecular Weight	562.99600
Flash Point	476.9ºC
Exact Mass	562.17200
PSA	192.62000
LogP	2.81610
Index of Refraction	1.698

5-iminodaunorubicin hydrochloride

aromatic/heteroaromatic sulfonamide 14

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5-imino-4-methyl-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonic acid amide

5-iminodaunomycin hydrochloride

1,3,4-Thiadiazole-2-sulfonamide,4,5-dihydro-5-imino-4-methyl

DC Chemicals Limited
China
Product Name: 5-Iminodaunorubicin hydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Iminodaunorubicin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥4340/10 mM * 1 mL in DMSO

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5-Iminodaunorubicin

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