Destruxin A

Modify Date: 2024-01-10 18:18:23

Destruxin A structure	Common Name	Destruxin A
	CAS Number	6686-70-0	Molecular Weight	577.71300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₄₇N₅O₇	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Destruxin A

Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities[1].

Name	(3S,10S,13S,16S,19R)-16-[(2S)-butan-2-yl]-10,11,14-trimethyl-13-propan-2-yl-3-prop-2-enyl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone
Synonym	More Synonyms

Description	Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170. [2]. Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77. [3]. Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71.

Description

Destruxin A (DA) is a cyclo-peptidic mycotoxin from the entomopathogenic fungus Metarhizium anisopliae, with insecticidal, anti-viral and antiproliferative activities[1].

Related Catalog

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Others >> Others

References

[1]. Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170.

[2]. Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77.

[3]. Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71.

Molecular Formula	C₂₉H₄₇N₅O₇
Molecular Weight	577.71300
Exact Mass	577.34800
PSA	152.41000
LogP	1.21150
Storage condition	-20°C

Destruxin A MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Risk Phrases	20/21/22-36/37/38-48
Safety Phrases	26-36-45
RIDADR	NONH for all modes of transport
RTECS	HH1500000

Concurrence of losing a chromosome and the ability to produce destruxins in a mutant of Metarhizium anisopliae.

FEMS Microbiol. Lett. 226(2) , 373-8, (2003)

In a previous study, a spontaneous subtilisin pr1A and pr1B gene-deficient mutant of the entomopathogenic fungus Metarhizium anisopliae strain V275 has been identified [Wang, C.-S. et al. (2002) FEMS ...

Synthesis and biological evaluation of destruxin A and related analogs.

J. Pept. Res. 58(1) , 1-11, (2001)

This report describes the development of an efficient solid-phase synthesis protocol and adaptation of reported solution phase procedures for the synthesis of the cyclic depsihexapeptide destruxin A a...

Non-cyclic AMP-dependent, positive inotropic cyclodepsipeptides with negative chronotropy.

J. Pharmacol. Exp. Ther. 290(3) , 1006-12, (1999)

The effects of natural cyclodepsipeptides (CDPs) on isolated rat cardiac tissue preparations were examined in vitro. Destruxin A, destruxin B (DB), roseotoxin B (RB), and roseocardin (RC), a novel CDP...

Destruxin A from Metarrhizium anisopliae

Destruxin A

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