Roxyl-WL
Modify Date: 2025-09-19 17:54:56
Roxyl-WL structure
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Common Name | Roxyl-WL | ||
|---|---|---|---|---|
| CAS Number | 667887-37-8 | Molecular Weight | 370.364 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 685.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C20H14N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 368.1±34.3 °C | |
Use of Roxyl-WLRoxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM; displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases; effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs), significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally. |
| Name | 1,5-Dibenzyl[1,2,3]triazolo[4,5-f]benzotriazole-4,8(1H,5H)-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM; displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases; effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs), significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally. |
|---|---|
| References | References 1. Xu G, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1089-1094. View Related Products by Target Indoleamine 2,3-Dioxygenase (IDO) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 685.1±65.0 °C at 760 mmHg |
| Molecular Formula | C20H14N6O2 |
| Molecular Weight | 370.364 |
| Flash Point | 368.1±34.3 °C |
| Exact Mass | 370.117828 |
| LogP | 3.88 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.783 |
| InChIKey | RDIIRJQNPUDIHM-UHFFFAOYSA-N |
| SMILES | O=C1c2nnn(Cc3ccccc3)c2C(=O)c2nnn(Cc3ccccc3)c21 |
| 1,2,3-Triazolo[4,5-f][1,2,3]benzotriazole-4,8(1H,5H)-dione, 1,5-bis(phenylmethyl)- |
| 1,5-Dibenzyl[1,2,3]triazolo[4,5-f]benzotriazole-4,8(1H,5H)-dione |