Roxyl-WL

Names

[ Name ]:
Roxyl-WL

[Synonym ]:
1,2,3-Triazolo[4,5-f][1,2,3]benzotriazole-4,8(1H,5H)-dione, 1,5-bis(phenylmethyl)-
1,5-Dibenzyl[1,2,3]triazolo[4,5-f]benzotriazole-4,8(1H,5H)-dione

Biological Activity

[Description]:

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM; displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases; effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs), significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally.

[References]

References 1. Xu G, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1089-1094. View Related Products by Target Indoleamine 2,3-Dioxygenase (IDO)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
685.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₄N₆O₂

[ Molecular Weight ]:
370.364

[ Flash Point ]:
368.1±34.3 °C

[ Exact Mass ]:
370.117828

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.783

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.