6-Monohydroxyflavone

Modify Date: 2024-01-03 00:34:22

6-Monohydroxyflavone Structure
6-Monohydroxyflavone structure
Common Name 6-Monohydroxyflavone
CAS Number 6665-83-4 Molecular Weight 238.238
Density 1.3±0.1 g/cm3 Boiling Point 450.1±45.0 °C at 760 mmHg
Molecular Formula C15H10O3 Melting Point 234-236 °C(lit.)
MSDS N/A Flash Point 176.3±22.2 °C

 Use of 6-Monohydroxyflavone


6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].

 Names

Name 6-Hydroxyflavone
Synonym More Synonyms

 6-Monohydroxyflavone Biological Activity

Description 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
Related Catalog
References

[1]. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52.

[2]. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560.

[3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 450.1±45.0 °C at 760 mmHg
Melting Point 234-236 °C(lit.)
Molecular Formula C15H10O3
Molecular Weight 238.238
Flash Point 176.3±22.2 °C
Exact Mass 238.062988
PSA 50.44000
LogP 3.72
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.666

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
WGK Germany 3
HS Code 2914400090

 Synthetic Route

 Customs

HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

EINECS 229-704-8
4H-1-Benzopyran-4-one, 6-hydroxy-2-phenyl-
6-Monohydroxyflavone
MFCD00017329
6-hydroxy-2-phenylchromen-4-one
6-Hydroxy-2-phenyl-4H-chromen-4-one