[2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamide
Modify Date: 2024-01-13 15:28:54
![[2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamide Structure](https://www.chemsrc.com/caspic/192/66537-55-1.png)
[2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamide structure
|
Common Name | [2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamide | ||
|---|---|---|---|---|
| CAS Number | 66537-55-1 | Molecular Weight | 394.44900 | |
| Density | 1.449g/cm3 | Boiling Point | 1023.2ºC at 760 mmHg | |
| Molecular Formula | C16H22N6O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 572.6ºC | |
Use of [2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamideMK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome[1][2]. |
| Name | (2S)-N-[(2S)-1-[(4S)-4-Carbamoyl-1,3-thiazolidin-3-yl]-3-(1H-imid azol-5-yl)-1-oxo-2-propanyl]-6-oxo-2-piperidinecarboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | MK771 (5 mg/kg；腹腔注射) 诱导小鼠眨眼和前爪舔[1]。 MK771 (10 ng-10 µg/小鼠；i.c.v.) 在小鼠体内产生高热反应[2]。 Animal Model: 20-30 g, male MF1 mice[1] Dosage: 5 mg/kg Administration: I.p. Result: Induced blinking and forepaw licking in both acutely isolated and paired mice. Animal Model: 20-30 g, male MF1 mice[1] Dosage: 0.25-60 mg/kg Administration: I.p. Result: Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg. Animal Model: 25-30 g, Male Swiss-Webster mice[2] Dosage: 10 ng-10 µg/mouse Administration: I.c.v. Result: Produced a hyperthermic response for 4 h followed by a return to normal temperature. |
| References |
| Density | 1.449g/cm3 |
|---|---|
| Boiling Point | 1023.2ºC at 760 mmHg |
| Molecular Formula | C16H22N6O4S |
| Molecular Weight | 394.44900 |
| Flash Point | 572.6ºC |
| Exact Mass | 394.14200 |
| PSA | 183.55000 |
| LogP | 0.69630 |
| Index of Refraction | 1.632 |
|
~%
[2S-[2R*[R*(R*)... CAS#:66537-55-1 |
| Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698 |
|
~%
[2S-[2R*[R*(R*)... CAS#:66537-55-1 |
| Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698 |
|
~%
[2S-[2R*[R*(R*)... CAS#:66537-55-1 |
| Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698 |
|
~%
[2S-[2R*[R*(R*)... CAS#:66537-55-1 |
| Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698 |
|
~%
[2S-[2R*[R*(R*)... CAS#:66537-55-1 |
| Literature: Nutt; Holly; Homnick; Hirschmann; Veber; Arison Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 692 - 698 |
![[*]Aad-His(DNP)-Tzl-NH2 structure](https://www.chemsrc.com/caspic/149/77897-79-1.png)
| <*>Aad-His-Tzl-NH2 |
| {2S-[2R*(R*(R*))]}-N-{2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl}-6-oxopiperidine-2-carboxamide |
| {2-Methyl-4-[bis-(2-jod-ethyl)-amino]-benzyliden}-malononitril |
| {4-[bis(2-iodoethyl)amino]-2-methylbenzylidene}propanedinitrile |