2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine

Modify Date: 2024-01-04 12:51:03

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure
2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine structure
Common Name 2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine
CAS Number 66356-53-4 Molecular Weight 214.328
Density 1.1±0.1 g/cm3 Boiling Point 292.9±40.0 °C at 760 mmHg
Molecular Formula C10H18N2OS Melting Point 96-97 °C(lit.)
MSDS N/A Flash Point 130.9±27.3 °C

 Names

Name Ranitidine Impurity B
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 292.9±40.0 °C at 760 mmHg
Melting Point 96-97 °C(lit.)
Molecular Formula C10H18N2OS
Molecular Weight 214.328
Flash Point 130.9±27.3 °C
Exact Mass 214.113983
PSA 67.70000
LogP 0.83
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.548

 MSDS

Name: 2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Material Safety Data Sheet
Synonym:
CAS: 66356-53-4
Section 1 - Chemical Product MSDS Name:2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
66356-53-4 2-[([5-[(Dimethylamino)methyl]-2-furyl 95+% 266-330-4
Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 66356-53-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H18N2OS
Molecular Weight: 214

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, acrid smoke and fumes.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 66356-53-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE LIQUID, N.O.S.*
Hazard Class: 8
UN Number: 1760
Packing Group: III
IMO
Shipping Name: CORROSIVE LIQUID, N.O.S.
Hazard Class: 8
UN Number: 1760
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE LIQUID, N.O.S.
Hazard Class: 8
UN Number: 1760
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 66356-53-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 66356-53-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 66356-53-4 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes C:Corrosive
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45
RIDADR 2735
HS Code 2932190090

 Synthetic Route

~70%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Navarro; Almeida; Anaya; Moran; Grande; Caballero; Palacios; Montero; San Roman Pharmazie, 1995 , vol. 50, # 1 p. 12 - 15

~66%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Chachula, Stanislaw; Grynkiewicz, Grzegorz; Szczycinski, Bohdan Polish Journal of Chemistry, 1990 , vol. 64, # 7 p. 619 - 622

~94%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Mascal, Mark; Dutta, Saikat Green Chemistry, 2011 , vol. 13, # 11 p. 3101 - 3102

~%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Polish Journal of Chemistry, , vol. 64, # 7 p. 619 - 622

~%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Pharmazie, , vol. 50, # 1 p. 12 - 15

~%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Green Chemistry, , vol. 13, # 11 p. 3101 - 3102

~%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Green Chemistry, , vol. 13, # 11 p. 3101 - 3102

~%

2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine Structure

2-[([5-[(Dimeth...

CAS#:66356-53-4

Literature: Polish Journal of Chemistry, , vol. 64, # 7 p. 619 - 622

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Synonyms

EINECS 266-330-4
2-[({5-[(Dimethylamino)methyl]-2-furyl}methyl)sulfanyl]ethanamine
5-((2-aminoethyl)thiomethyl)-N,N-dimethyl-2-furanmethanamine
2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethanamine
2-(2-Aminoethylthiomethyl)-5-dimethylaminomethylfuran
2-(5-Dimethylaminomethyl-furan-2-yl methylsulfanyl)-ethylamine
MFCD00277202
2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethanamine
2-Furanmethanamine, 5-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-
5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furfurylamine
2-[[[5-(dimethylamine)methyl-2-furrny]methyl]thio]ethanamine; (Ranitidine intermediate)
2-[([5-[(Dimethylamino)methyl]-2-furyl]methyl)thio]ethan-1-amine
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