N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide

Modify Date: 2025-08-25 20:19:52

N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide structure	Common Name	N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide
	CAS Number	639089-73-9	Molecular Weight	452.576
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₈N₈OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide

VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].

Name	N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]propanamide
Synonym	More Synonyms

Description	VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
References	[1]. Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50(3):518-27. [2]. Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49(3):559-69.

Description

VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].

Related Catalog

Signaling Pathways >> Epigenetics >> Aurora Kinase

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

References

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₂H₂₈N₈OS
Molecular Weight	452.576
Exact Mass	452.210663
LogP	1.34
Index of Refraction	1.684
InChIKey	LCQYMDMUCJFFKN-UHFFFAOYSA-N
SMILES	CCC(=O)Nc1ccc(Sc2nc(Nc3cc(C)[nH]n3)cc(N3CCN(C)CC3)n2)cc1

Propanamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-

N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]propanamide