KKII5
Modify Date: 2024-01-29 19:01:54
KKII5 structure
|
Common Name | KKII5 | ||
|---|---|---|---|---|
| CAS Number | 6381-55-1 | Molecular Weight | 266.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H14N2S | Melting Point | 181-183ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of KKII5KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1]. |
| Name | 4,6-diphenyl-3,4-dihydro-1H-pyrimidine-2-thione |
|---|---|
| Synonym | More Synonyms |
| Description | KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 19 μM (LOX-1)[1] |
| In Vitro | KKII5 与腔体的 HIS499 相互作用，通过在分子的苯环和 HIS499 的咪唑环之间形成一个 π-π 堆叠相互作用[1]。 KKII5 (100 μM) 对脂质过氧化有明显抑制作用，抑制率达 98% [1]。 |
| References |
| Melting Point | 181-183ºC |
|---|---|
| Molecular Formula | C16H14N2S |
| Molecular Weight | 266.36 |
| Exact Mass | 266.08800 |
| PSA | 56.15000 |
| LogP | 3.90410 |
| Risk Phrases | 36/37/38 |
|---|---|
| Safety Phrases | 26-36/37/39 |
| 4,6-diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione |
| HMS558F13 |
| HMS2663P05 |