AH-7614

Modify Date: 2024-01-15 10:04:33

AH-7614 structure	Common Name	AH-7614
	CAS Number	6326-06-3	Molecular Weight	351.41900
	Density	1.37g/cm3	Boiling Point	505.9ºC at 760mmHg
	Molecular Formula	C₂₀H₁₇NO₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	259.8ºC

Use of AH-7614

AH-7614 is a potent and selective FFA4 antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is also a negative allosteric modulator (NAM) of FFA4. AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1][2].

Name	N-Xanthen-9-yl-toluol-4-sulfonamid
Synonym	More Synonyms

Description	AH-7614 is a potent and selective FFA4 antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is also a negative allosteric modulator (NAM) of FFA4. AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR120 Research Areas >> Metabolic Disease
Target	pIC50: 7.1 (human FFA4)[1]
In Vitro	AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells[1]. AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells[1]. AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70)[2]. AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4[2].
In Vivo	AH7614 (50 μg; intratumoral injection once every 4 d for 20 d) reduces the tumor growth in mice[3]. AH7614 (50 μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin[3].
References	[1]. Sparks SM, et, al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. [2]. Watterson KR, et, al. Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4. Mol Pharmacol. 2017 Jun;91(6):630-641. [3]. Wang X, et, al. Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis. EBioMedicine. 2019 Feb;40:251-262.

Density	1.37g/cm3
Boiling Point	505.9ºC at 760mmHg
Molecular Formula	C₂₀H₁₇NO₃S
Molecular Weight	351.41900
Flash Point	259.8ºC
Exact Mass	351.09300
PSA	63.78000
LogP	5.64030
Index of Refraction	1.685

HS Code	2935009090

N/A

CAS#:13707-49-8

2-trimethylsily...

CAS#:88284-48-4

~10%

AH-7614

CAS#:6326-06-3

Literature: Lu, Shan-Shan; Lu, Chong-Dao Synlett, 2013 , vol. 24, # 5 art. no. ST-2012-W1105-L, p. 640 - 644

Xanthene

CAS#:92-83-1

[N-(p-Toluenesu...

CAS#:55962-05-5

~75%

AH-7614

CAS#:6326-06-3

Literature: Liu, Yungen; Guan, Xiangguo; Wong, Ella Lai-Ming; Liu, Peng; Huang, Jie-Sheng; Che, Chi-Ming Journal of the American Chemical Society, 2013 , vol. 135, # 19 p. 7194 - 7204

xanthydrol

CAS#:90-46-0

4-Toluenesulfonamide

CAS#:70-55-3

AH-7614

CAS#:6326-06-3

Literature: Phillips; Frank Journal of Organic Chemistry, 1944 , vol. 9, p. 9,10

Xanthone

CAS#:90-47-1

4-Toluenesulfonamide

CAS#:70-55-3

AH-7614

CAS#:6326-06-3

Literature: Weng, Zhen-Tao; Li, Yuan; Tian, Shi-Kai Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 8095 - 8099

9H-Xanthen-9-amine

CAS#:35598-63-1

Tosyl chloride

CAS#:98-59-9

AH-7614

CAS#:6326-06-3

Literature: Sparks, Steven M.; Chen, Grace; Collins, Jon L.; Danger, Dana; Dock, Steven T.; Jayawickreme, Channa; Jenkinson, Stephen; Laudeman, Christopher; Leesnitzer, M. Anthony; Liang, Xi; Maloney, Patrick; McCoy, David C.; Moncol, David; Rash, Vincent; Rimele, Thomas; Vulimiri, Padmaja; Way, James M.; Ross, Sean Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 3100 - 3103

N/A

CAS#:20114-58-3

AH-7614

CAS#:6326-06-3

Literature: Weng, Zhen-Tao; Li, Yuan; Tian, Shi-Kai Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 8095 - 8099

Precursor 7
CAS#:88284-48-4 2-trimethylsily... CAS#:92-83-1 Xanthene CAS#:90-46-0 xanthydrol CAS#:70-55-3 4-Toluenesulfonamide
CAS#:90-47-1 Xanthone CAS#:35598-63-1 9H-Xanthen-9-amine CAS#:98-59-9 Tosyl chloride
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

4-methyl-N-9H-xanthen-9-yl-Benzamide

N-xanthen-9-yl-p-toluamide

N-xanthen-9-yl-toluene-4-sulfonamide

N-xanthyl-p-toluenesulfonamide

DC Chemicals Limited
China
Product Name: AH-7614
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzenesulfonamide,4-methyl-N-9H-xanthen-9-yl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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