Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

…, C Jayawickreme, S Jenkinson, C Laudeman…

Index: Sparks, Steven M.; Chen, Grace; Collins, Jon L.; Danger, Dana; Dock, Steven T.; Jayawickreme, Channa; Jenkinson, Stephen; Laudeman, Christopher; Leesnitzer, M. Anthony; Liang, Xi; Maloney, Patrick; McCoy, David C.; Moncol, David; Rash, Vincent; Rimele, Thomas; Vulimiri, Padmaja; Way, James M.; Ross, Sean Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 3100 - 3103

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Citation Number: 20

Abstract

Abstract The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8 and 39 is presented herein.