2,4-Imidazolidinedione,5-ethyl-5-phenyl-

Modify Date: 2024-01-02 12:17:51

2,4-Imidazolidinedione,5-ethyl-5-phenyl- Structure
2,4-Imidazolidinedione,5-ethyl-5-phenyl- structure
 Common Name 2,4-Imidazolidinedione,5-ethyl-5-phenyl-
CAS Number 631-07-2 Molecular Weight 204.22500
Density 1.173 g/cm3 Boiling Point N/A
Molecular Formula C11H12N2O2 Melting Point 195-200ºC
MSDS USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Names

Name rac N-Desmethyl Mephenytoin
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.173 g/cm3
Melting Point 195-200ºC
Molecular Formula C11H12N2O2
Molecular Weight 204.22500
Exact Mass 204.09000
PSA 58.20000
LogP 1.78890
Index of Refraction 1.538
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU2452000
CHEMICAL NAME :
Hydantoin, 5-ethyl-5-phenyl-
CAS REGISTRY NUMBER :
631-07-2
LAST UPDATED :
199012
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C11-H12-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LDTU** "Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - excitement
REFERENCE :
HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 Volume(issue)/page/year: -,-,1933
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases 26
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS MU2452000

 Synthetic Route

2-isocyanato-2-phenylbutanenitrile structure

2-isocyanato-2-...

CAS#:33875-36-4

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2,4-Imidazolidinedione,5-ethyl-5-phenyl- Structure

2,4-Imidazolidi...

CAS#:631-07-2
Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 313, # 6 p. 538 - 543
(1-cyano-1-phenyl-propyl)-urea structure

(1-cyano-1-phen...

CAS#:75356-44-4

~%

2,4-Imidazolidinedione,5-ethyl-5-phenyl- Structure

2,4-Imidazolidi...

CAS#:631-07-2
Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 313, # 6 p. 538 - 543

 Precursor & DownStream

Precursor  1

DownStream  0

 Articles25

More Articles
Pharmacodynamics of cytochrome P450 2B induction by phenobarbital, 5-ethyl-5-phenylhydantoin, and 5-ethyl-5-phenyloxazolidinedione in the male rat liver or in cultured rat hepatocytes.

Chem. Res. Toxicol. 6(2) , 188-96, (1993)

The pharmacodynamics of rat hepatic cytochrome P450 2B (P450 2B) induction by phenobarbital (PB) and two structural congeners, dl-5-ethyl-5-phenylhydantoin (EPH) and dl-5-ethyl-5-phenyloxazolidinedion...
A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats.

Biochem. Pharmacol. 43(5) , 1079-87, (1992)

Phenobarbital (PB) and certain structurally-related compounds induce a variety of hepatic drug-metabolizing enzymes in many strains of rats. Thus, following administration of PB (300, 500 ppm), barbit...
Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.

Arch. Biochem. Biophys. 429(1) , 1-15, (2004)

Three series of N-3 alkyl substituted phenytoin, nirvanol, and barbiturate derivatives were synthesized and their inhibitor potencies were tested against recombinant CYP2C19 and CYP2C9 to probe the in...

 Synonyms

EINECS 211-150-3
(+/-)-5-ethyl-5-phenylhydantoin
MFCD00022401
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