MRS 2500 tetraammonium salt
Modify Date: 2025-08-21 17:01:33
MRS 2500 tetraammonium salt structure
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Common Name | MRS 2500 tetraammonium salt | ||
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| CAS Number | 630103-23-0 | Molecular Weight | 629.285 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H30IN9O8P2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRS 2500 tetraammonium saltMRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (Ki=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Antithrombotic activity[1][2][3]. |
| Name | [(1R,2S,4S,5S)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate tetraammoniate |
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| Synonym | More Synonyms |
| Description | MRS2500 tetraammonium is a potent, selective and stable antagonist of the P2Y1 receptor (Ki=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Antithrombotic activity[1][2][3]. |
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| Related Catalog | |
| In Vitro | MRS2500 tetraammonium inhibits platelet aggregation to 10 μM ADP with an IC50 of 0.95 nM in human washed platelets. MRS2500 tetraammonium inhibits platelet aggregation to 10μM ADP with an IC50 of 0.49 μM in human PRP[4]. |
| In Vivo | MRS2500 (2 mg/kg; i.v.) decreases acute systemic thromboembolism through selective inhibition of the P2Y1 receptor[3]. MRS2500 exhibited strong antithrombotic efficacy in the prevention of arterial thrombosis in the monkey ECAT model[4].. Animal Model: 20-25 g WT Male mice (acute vascular occlusion model)[3] Dosage: 2 mg/kg Administration: Intravenous Result: Reduced platelet consumption. |
| References |
| Molecular Formula | C13H30IN9O8P2 |
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| Molecular Weight | 629.285 |
| Exact Mass | 629.073730 |
| [(1R,2S,4S,5S)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate tetraammoniate |
| Bicyclo[3.1.0]hexane-1-methanol, 4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)-, dihydrogen phosphate (ester), tetraammonium salt, (1R,2S,4S,5S)- |