sodium gualenate

Modify Date: 2024-01-02 10:17:28

sodium gualenate structure	Common Name	sodium gualenate
	CAS Number	6223-35-4	Molecular Weight	300.348
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₇NaO₃S	Melting Point	98°C(lit.)
	MSDS	N/A	Flash Point	N/A

Use of sodium gualenate

Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.

Name	sodium,3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate
Synonym	More Synonyms

Description	Sodium gualenate (Guaiazulenesulfonate sodium) is a hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Sodium gualenate is an unstable compound, which is gradually decomposed in the solid state at room temperature. When heated, Sodium gualenate decomposes almost completely within 1 week. It was found that a kneaded mixture of Sodium gualenate and cornstarch (weight ratio; 1:250) for tableting with water is stable. So, during production, Sodium gualenate could be stabilized using water[1]. Sodium gualenate slightly inhibits the histamine release from rat peritoneal mast cells and strongly inhibits the leukocyte emigration induced by fMLP[2].
In Vivo	Sodium gualenate has been frequently used for the treatment of human gastritis. Cytoprotection is defined as the main mechanism of Sodium gualenate to protect the mucosa of the stomach and the antipeptic actions in vivo have also been shown[2].
References	[1]. Nakamichi K, et al. Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 2003 Nov;56(3):347-54. [2]. Cao T, et al. Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent. Chem Biol Drug Des. 2016 Aug;88(2):264-71.

Melting Point	98°C(lit.)
Molecular Formula	C₁₅H₁₇NaO₃S
Molecular Weight	300.348
Exact Mass	300.079620
PSA	65.58000
LogP	4.51650

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CO4826000

CHEMICAL NAME :: 1-Azulenesulfonic acid, 5-isopropyl-3,8-dimethyl-, sodium salt

CAS REGISTRY NUMBER :: 6223-35-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H18-O3-S.Na

MOLECULAR WEIGHT :: 301.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: SHNSAS Shinryo to Shinyaku. Medical Consultation and New Remedies. (Iji Shuppan Sha, 1-2-8 Shinkawa, Chuo-Ku, Tokyo 104, Japan) V.1- 1964- Volume(issue)/page/year: 11,2533,1974

RTECS	CO4826000
HS Code	2904100000

guaiazulene

CAS#:489-84-9

sodium gualenate

CAS#:6223-35-4

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5722 - 5725

3,8-dimethyl-5-...

CAS#:16915-32-5

sodium gualenate

CAS#:6223-35-4

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 19 p. 5722 - 5725

Precursor 2
CAS#:489-84-9 guaiazulene CAS#:16915-32-5 3,8-dimethyl-5-...
DownStream 1
CAS#:6223-36-5 ethyl 3,8-dimet...

HS Code	2904100000
Summary	2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

sodium 5-isopropyl-3,8-dimethylazulene-1-sulfonate

Gualenate de sodium

sodium gualenate

Azulene sulfonate sodium

5-isopropyl-3,8-dimethyl-azulene-1-sulfonic acid,sodium-salt

5-Isopropyl-3,8-dimethyl-azulen-1-sulfonsaeure,Natrium-Salz

Natrii gualenas

Sodium guiazulene sulfonate

Gualenato sodidico

Azulen SN

Azupromin

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sodium gualenate
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Sodium gualenate
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Sodium gualenate
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Purity: 99.0%
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Contact: Anson

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