1-(3-Hydroxyphenyl)urea

Modify Date: 2025-08-25 22:14:57

1-(3-Hydroxyphenyl)urea structure	Common Name	1-(3-Hydroxyphenyl)urea
	CAS Number	621-42-1	Molecular Weight	152.151
	Density	1.4±0.1 g/cm3	Boiling Point	313.1±25.0 °C at 760 mmHg
	Molecular Formula	C₈H₉NO₂	Melting Point	145-148 °C(lit.)
	MSDS	Chinese USA	Flash Point	143.2±23.2 °C
	Symbol	GHS07	Signal Word	Warning

Use of 1-(3-Hydroxyphenyl)urea

Metacetamol is an isomer of paracetamol and it similarly exhibits polymorphism.

Name	metacetamol
Synonym	More Synonyms

Density	1.4±0.1 g/cm3
Boiling Point	313.1±25.0 °C at 760 mmHg
Melting Point	145-148 °C(lit.)
Molecular Formula	C₈H₉NO₂
Molecular Weight	152.151
Flash Point	143.2±23.2 °C
Exact Mass	152.058578
PSA	49.33000
LogP	0.36
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.690
Storage condition	2-8°C

1-(3-Hydroxyphenyl)urea MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE4100000

CHEMICAL NAME :: Acetanilide, 3'-hydroxy-

CAS REGISTRY NUMBER :: 621-42-1

BEILSTEIN REFERENCE NO. :: 0907998

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H9-N-O2

MOLECULAR WEIGHT :: 151.18

WISWESSER LINE NOTATION :: QR CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1025 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 28,447,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6632 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 198 (estimated) No. of Female Employees: 151 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn;Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	2811
WGK Germany	2
RTECS	AE4100000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29242995

Precursor 10
CAS#:108-24-7 Ethanoic anhydride CAS#:591-27-5 3-Aminophenol CAS#:6317-89-1 3-Acetamidophen... CAS#:554-84-7 3-Nitrophenol
CAS#:10387-40-3 Potassium thioa... CAS#:60-35-5 Acetamide CAS#:631-61-8 Ammonium acetate CAS#:108-43-0 3-Chlorophenol
CAS#:75-05-8 Acetonitrile CAS#:107866-54-6 (R)-(-)-3-CHLOR...
DownStream 10
CAS#:4294-95-5 2-Amino-4-metho... CAS#:39489-79-7 2,4-Dichloro-5-... CAS#:23079-68-7 3-BUTOXYANILINE CAS#:19223-12-2 N-[3-[2-(2-nitr...
CAS#:27153-17-9 N-(3-methoxyphe... CAS#:26093-31-2 7-Amino-4-methy... CAS#:98446-49-2 5-Amino-2,4-dic... CAS#:6850-39-1 3-Aminocyclohexanol
CAS#:591-27-5 3-Aminophenol CAS#:67669-19-6 5-Acetylamino-2...

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Developing structure-activity relationships for the prediction of hepatotoxicity.

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Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Urea, N-(3-hydroxyphenyl)-

3-ACETAMIDOPHENOL

1-(3-Hydroxyphenyl)urea

m-Acetamidophenol

3-hydroxyacetoanilide

N-Acetyl-m-aminophenol

m-hydroxyacetanilide

MFCD00002263

3'-Hydroxyacetanilide

m-acetylaminophenol

3-acetylaminophenol

Metacetamol

3-acetamino-phenol

EINECS 210-687-0

Bosutinib Impurity 10

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1-(3-Hydroxyphenyl)urea
Price: Check
Purity: 99.72%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1-(3-Hydroxyphenyl)urea
Price: ￥76.0/10g ￥46.0/5g ￥386.0/100g ￥116.0/25g
Purity: 98.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Metacetamol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Metacetamol
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Metacetamol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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1-(3-Hydroxyphenyl)urea

Use of 1-(3-Hydroxyphenyl)urea

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