5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

Modify Date: 2025-09-01 12:55:32

5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide Structure
5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide structure
 Common Name 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
CAS Number 612530-44-6 Molecular Weight 212.22600
Density 1.483 Boiling Point N/A
Molecular Formula C8H8N2O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide


PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.

 Names

Name 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
Synonym More Synonyms

  Biological Activity

Description PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.
Related Catalog
References

[1]. Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.

[2]. Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.

 Chemical & Physical Properties

Density 1.483
Molecular Formula C8H8N2O3S
Molecular Weight 212.22600
Exact Mass 212.02600
PSA 78.35000
LogP 1.28930
InChIKey LDCZCUKQWRZSDT-UHFFFAOYSA-N
SMILES O=C1CN(c2ccccc2)S(=O)(=O)N1
Storage condition 2-8℃

 Synonyms

PTP1B-IN-1
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Chemsrc provides CAS#:612530-44-6 MSDS, density, melting point, boiling point, structure, etc. Its name is 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide>> amp version: 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

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