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5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

Names

[ CAS No. ]:
612530-44-6

[ Name ]:
5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

[Synonym ]:
PTP1B-IN-1

Biological Activity

[Description]:

PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Metabolic Disease

[References]

[1]. Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.

[2]. Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.


[Related Small Molecules]

SHP099 hydrochloride | LB-100 | Salubrinal | Calyculin A | SF1670 | Stibogluconate sodium | TPI-1 | MSI-1436 lactate | Microcystin-LR | Sodium orthovanadate | GSK 2830371 | PTP1B-IN-2 | Rosiptor | NSC 663284(DA3003-1) | TCS 401

Chemical & Physical Properties

[ Density]:
1.483

[ Molecular Formula ]:
C8H8N2O3S

[ Molecular Weight ]:
212.22600

[ Exact Mass ]:
212.02600

[ PSA ]:
78.35000

[ LogP ]:
1.28930

[ Storage condition ]:
2-8℃

Related Compounds