N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
Modify Date: 2025-09-26 19:02:25
N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine structure
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Common Name | N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine | ||
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| CAS Number | 61136-12-7 | Molecular Weight | 478.45100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H30N4O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-acetyl-nor-muramyl-L-alanyl-D-isoglutamineAlmurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3]. |
| Name | (4R)-4-[[(2S)-2-[[2-[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxyacetyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid |
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| Synonym | More Synonyms |
| Description | Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3]. |
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| Related Catalog | |
| In Vivo | Almurtide (80 mg/kg; 每天 1 次, 连续 4 天; 腹腔注射，静脉注射或皮下注射) 非特异性刺激巨噬细胞，对单核增生李斯特菌有抗感染活性。同时，它缺少口服活性，和庆大霉素 (HY-A0276A) 之间存在协同作用[2]。 Almurtide (100 μg/mouse; 皮下注射; 2-3 个月 1 次, 共 2 次) 防止低剂量 Friend 白血病病毒引起的 SJL/J 小鼠的红白血病，延缓 RIII/Imr 小鼠自发乳腺肿瘤的发生[3]。 |
| References |
| Molecular Formula | C18H30N4O11 |
|---|---|
| Molecular Weight | 478.45100 |
| Exact Mass | 478.19100 |
| PSA | 266.14000 |
| InChIKey | NWMHDZMRVUOQGL-CZEIJOLGSA-N |
| SMILES | CC(=O)NC(C=O)C(OCC(=O)NC(C)C(=O)NC(CCC(=O)O)C(N)=O)C(O)C(O)CO |
| N-Acetyl-nor-muramyl-L-alanyl-D-isoglutamine |
| UNII-1DCO35D4OR |
| Nor-MDP |