methopromazine

Modify Date: 2025-08-25 15:17:01

methopromazine Structure
methopromazine structure
 Common Name methopromazine
CAS Number 61-01-8 Molecular Weight 314.44500
Density 1.143g/cm3 Boiling Point 461.8ºC at 760 mmHg
Molecular Formula C18H22N2OS Melting Point N/A
MSDS N/A Flash Point 233.1ºC

 Names

Name 3-(2-methoxyphenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.143g/cm3
Boiling Point 461.8ºC at 760 mmHg
Molecular Formula C18H22N2OS
Molecular Weight 314.44500
Flash Point 233.1ºC
Exact Mass 314.14500
PSA 41.01000
LogP 4.31460
Index of Refraction 1.603

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SO7600000
CHEMICAL NAME :
Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
CAS REGISTRY NUMBER :
61-01-8
LAST UPDATED :
198209
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H22-N2-O-S
MOLECULAR WEIGHT :
314.48
WISWESSER LINE NOTATION :
T C666 BN ISJ B3N1&1 EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
730 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
95 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
408 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
112 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960

 Synthetic Route

2-Methoxyphenothiazine structure

2-Methoxyphenot...

CAS#:1771-18-2

3-Chloro-N,N-dimethylpropan-1-amine structure

3-Chloro-N,N-di...

CAS#:109-54-6

~%

methopromazine Structure

methopromazine

CAS#:61-01-8

Literature: Soc. Usines Chim. Rhone-Poulenc Patent: US2785160 , 1952 ; Full Text Show Details Soc. Usines Chim. Rhone-Poulenc Patent: DE940829 , 1952 ;
N'-[2-(2-bromo-phenylsulfanyl)-5-methoxy-phenyl]-N,N-dimethyl-propanediyldiamine structure

N'-[2-(2-bromo-...

CAS#:107627-98-5

~%

methopromazine Structure

methopromazine

CAS#:61-01-8

Literature: Soc. Usines Chim. Rhone-Poulenc Patent: US2769002 , 1954 ;
Methanol structure

Methanol

CAS#:67-56-1

Chlorpromazine hydrochloride structure

Chlorpromazine ...

CAS#:69-09-0

~0%

methopromazine Structure

methopromazine

CAS#:61-01-8

Promazine hydrochloride structure

Promazine hydro...

CAS#:53-60-1

Literature: Garcia, Carmelo; Pinero, Luis; Oyola, Rolando; Arce, Rafael Photochemistry and Photobiology, 2009 , vol. 85, # 1 p. 160 - 170

 Synonyms

2-Methoxypromazine
Methopromazinum [INN-Latin]
Neoproma
[3-(2-methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amine
RP 4632
Methoxypromazine
Tentone
2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine
Methopromazine
Tenton
Methopromazin
Metopromazina [INN-Spanish]
Levopromazine
[3-(2-Methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amin
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