Guanabenz

Modify Date: 2025-08-27 18:49:22

Guanabenz structure	Common Name	Guanabenz
	CAS Number	60329-03-5	Molecular Weight	231.08200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈H₈Cl₂N₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Guanabenz

(E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2].

Name	Guanabenz

Description	(E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	α2-adrenoceptor, GADD34[1][2]
References	[1]. Sun X, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May;303:95-107. [2]. Xie J, et al. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies. J Pharm Biomed Anal. 2021 Oct 25;205:114331.

Molecular Formula	C₈H₈Cl₂N₄
Molecular Weight	231.08200
Exact Mass	230.01300
PSA	76.76000
LogP	3.00130

Precursor 0
DownStream 2
CAS#:83-38-5 2,6-Dichloroben... CAS#:79-17-4 Hydrazinecarbox...

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Guanabenz

Use of Guanabenz

Names

Guanabenz Biological Activity

Chemical & Physical Properties

Precursor & DownStream

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.