Methyldopate

Modify Date: 2024-01-06 06:49:29

Methyldopate Structure
Methyldopate structure
Common Name Methyldopate
CAS Number 6014-30-8 Molecular Weight 239.268
Density 1.2±0.1 g/cm3 Boiling Point 398.0±37.0 °C at 760 mmHg
Molecular Formula C12H17NO4 Melting Point N/A
MSDS N/A Flash Point 194.5±26.5 °C

 Use of Methyldopate


Methyldopate is an ethyl ester prodrug of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research [1].

 Names

Name Methyldopate
Synonym More Synonyms

 Methyldopate Biological Activity

Description Methyldopate is an ethyl ester prodrug of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research [1].
Related Catalog
In Vivo Methyldopate is hydrolysed in vivo to methyldopa[2].
References

[1]. P D Walson, et al. Metabolic disposition and cardiovascular effects of methyldopate in unanesthetized rhesus monkeys. J Pharmacol Exp Ther. 1975 Oct;195(1):151-8.

[2]. Hoskins JA, et al. Determination of alpha-methyldopa and methyldopate in human breast milk and plasma by ion-exchange chromatography using electrochemical detection. J Chromatogr. 1982 Jun 11;230(1):162-7.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 398.0±37.0 °C at 760 mmHg
Molecular Formula C12H17NO4
Molecular Weight 239.268
Flash Point 194.5±26.5 °C
Exact Mass 239.115753
LogP 0.81
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.573

 Synonyms

Ethyl 3-hydroxy-α-methyl-L-tyrosinate
Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, ethyl ester, L-
L-Methyldopa ethyl ester
3-Hydroxy-a-methyl-L-tyrosine Ethyl Ester
MFCD00865839
L-3-(3,4-Dihydroxyphenyl)-2-methylalanine ethyl ester
EINECS 219-720-3
2579Z4P04J
L-Tyrosine, 3-hydroxy-α-methyl-, ethyl ester
EINECS 219-821-2
Methyldopate
L-Methyldopate
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