ANB-NOS
ANB-NOS structure
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Common Name | ANB-NOS | ||
|---|---|---|---|---|
| CAS Number | 60117-35-3 | Molecular Weight | 305.203 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H7N5O6 | Melting Point | 131-133ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of ANB-NOSANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | 5-Azido-2-nitrobenzoic acid N-hydroxysuccinimide ester |
|---|---|
| Synonym | More Synonyms |
| Description | ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 131-133ºC |
|---|---|
| Molecular Formula | C11H7N5O6 |
| Molecular Weight | 305.203 |
| Exact Mass | 305.039642 |
| PSA | 159.25000 |
| LogP | 0.53 |
| InChIKey | FUOJEDZPVVDXHI-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=Nc1ccc([N+](=O)[O-])c(C(=O)ON2C(=O)CCC2=O)c1 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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~%
ANB-NOS CAS#:60117-35-3 |
| Literature: Bernardi, Dan; Ba, Lalla Aicha; Kirsch, Gilbert Synthesis, 2007 , # 1 p. 140 - 144 |
| Precursor 2 | |
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| DownStream 0 | |
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Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A2.
Biochemistry 16 , 5650-5654, (1977) Two novel heterobifunctional cross-linking reagents, which can be used to attach photoactivatable nitroaryl azides to primary amino groups of proteins, have been synthesized. The two compounds, N-5-az... |
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Covalent binding of biological samples to solid supports for scanning probe microscopy in buffer solution.
Biophys. J. 65(6) , 2437-46, (1993) Scanning force microscopy allows imaging of biological molecules in their native state in buffer solution. To this end samples have to be fixed to a flat solid support so that they cannot be displaced... |
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[Structural characterization of the somatostatin receptors on rat cerebrocortical membranes].
Nihon Naibunpi Gakkai Zasshi 66(10) , 1108-16, (1990) We characterized structurally the receptors for somatostatin in rat cerebral cortex by affinity labeling with [125I-Tyr1] somatostatin. [125I-Tyr1] somatostatin was cross-linked to cerebrocortical mem... |
| 1-[(5-Azido-2-nitrobenzoyl)oxy]-2,5-pyrrolidinedione |
| 2,5-Pyrrolidinedione, 1-[(5-azido-2-nitrobenzoyl)oxy]- |
| 2,5-Pyrrolidinedione, 1-((5-azido-2-nitrobenzoyl)oxy)- |
| (2,5-dioxopyrrolidin-1-yl) 5-azido-2-nitrobenzoate |