2761725-68-0
2761725-68-0 structure
- Name: NOS-IN-3
- Chemical Name: NOS-IN-3
- CAS Number: 2761725-68-0
- Molecular Formula: C10H15N3O
- Molecular Weight: 193.25
- Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
- Create Date: 2022-05-21 15:16:49
- Modify Date: 2024-01-16 20:03:56
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NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 µM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the treatment of inducible isoform involved diseases, such as septic shock[1].
| Name | NOS-IN-3 |
|---|
| Description | NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 µM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the treatment of inducible isoform involved diseases, such as septic shock[1]. |
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| Related Catalog | |
| Target |
IC50: 4.6 µM (iNOS), > 1000 µM (nNOS)[1] |
| In Vitro | NOS-IN-3 (Compound 9a) shows high iNOS selectivity without eNOS inhibition activity [1]. NOS-IN-3 (0-100 µM, 30 min) has little toxicity[1]. Cell Viability Assay[1] Cell Line: HUVECs Concentration: 10, 20, 50, 100, 500 µM Incubation Time: 30 min Result: Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced. |
| References |
| Molecular Formula | C10H15N3O |
|---|---|
| Molecular Weight | 193.25 |