Nikkomycin Z
Modify Date: 2024-01-03 11:45:43
Nikkomycin Z structure
|
Common Name | Nikkomycin Z | ||
|---|---|---|---|---|
| CAS Number | 59456-70-1 | Molecular Weight | 495.44000 | |
| Density | 1.646 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H25N5O10 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Nikkomycin ZNikkomycin Z, a nucleoside-peptide, is a selective competitive chitin synthesis inhibitor. Nikkomycin Z has antifungal effects and acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine[1]. |
| Name | nikkomycin Z |
|---|---|
| Synonym | More Synonyms |
| Description | Nikkomycin Z, a nucleoside-peptide, is a selective competitive chitin synthesis inhibitor. Nikkomycin Z has antifungal effects and acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.646 g/cm3 |
|---|---|
| Molecular Formula | C20H25N5O10 |
| Molecular Weight | 495.44000 |
| Exact Mass | 495.16000 |
| PSA | 250.32000 |
| Index of Refraction | 1.678 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| RTECS | BA2928200 |
|
SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes.
BMC Microbiol. 11 , 164, (2011) sabR is a pleiotropic regulatory gene which has been shown to positively regulate the nikkomycin biosynthesis and negatively affect the sporulation of Streptomyces ansochromogenes. In this study, we i... |
|
|
Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination.
Antimicrob. Agents Chemother. 56 , 1595-1598, (2012) Chitin and β-glucan are major cell wall components of Aspergillus spp. We investigated the antifungal activity of chitin synthesis inhibitors nikkomycin Z, polyoxin D, flufenoxuron, lufenuron, and tef... |
|
|
Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis.
FEBS J. 278(21) , 4122-35, (2011) As inhibitors of chitin synthase, nikkomycins have attracted interest as potential antibiotics. The biosynthetic pathway to these peptide nucleosides in Streptomyces tendae is only partially known. In... |
| Nikkomycin Z |
| MFCD00869648 |