N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Modify Date: 2024-04-03 10:01:41

N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride structure	Common Name	N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
	CAS Number	58934-46-6	Molecular Weight	407.37700
	Density	N/A	Boiling Point	503ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₈Cl₂N₂O	Melting Point	263°
	MSDS	USA	Flash Point	258ºC
	Symbol	GHS07	Signal Word	Warning

Use of N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Lorcainide hydrochloride is a antiarrhythmic agent with local anaesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Pharmacologically, this drug appears effective in suppressing reentry phenomena and ectopic pacemaker activity, especially in the ventricles.

Name	N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide,hydrochloride
Synonym	More Synonyms

Boiling Point	503ºC at 760 mmHg
Melting Point	263°
Molecular Formula	C₂₂H₂₈Cl₂N₂O
Molecular Weight	407.37700
Flash Point	258ºC
Exact Mass	406.15800
PSA	23.55000
LogP	5.52840

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1483700

CHEMICAL NAME :: Benzeneacetamide, N-(4-chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl )-, monohydrochloride

CAS REGISTRY NUMBER :: 58934-46-6

LAST UPDATED :: 199009

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H27-Cl-N2-O.Cl-H

MOLECULAR WEIGHT :: 407.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

4-chloro-2-phen...

CAS#:63260-75-3

2-Bromopropane

CAS#:75-26-3

N-(4-chlorophen...

CAS#:58934-46-6

Literature: Janssen Pharmaceutica N.V. Patent: US4126689 A1, 1978 ; Title/Abstract Full Text Show Details Janssen Pharmaceutica N.V. Patent: US4197304 A1, 1980 ;

Precursor 2
CAS#:63260-75-3 4-chloro-2-phen... CAS#:75-26-3 2-Bromopropane
DownStream 0

4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride

N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide hydrochloride

Lorcainide hydrochloride

Lorcainide hydrochloride (USAN)

Lorcainidhydrochlorid

R-15,889

DC Chemicals Limited
China
Product Name: Lorcainide hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Use of N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Synonyms