Diloxanide

Modify Date: 2024-01-02 16:08:42

Diloxanide structure	Common Name	Diloxanide
	CAS Number	579-38-4	Molecular Weight	234.07900
	Density	1.439g/cm3	Boiling Point	356.2ºC at 760 mmHg
	Molecular Formula	C₉H₉Cl₂NO₂	Melting Point	175°
	MSDS	N/A	Flash Point	169.2ºC

Use of Diloxanide

Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1].

Name	2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
Synonym	More Synonyms

Description	Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1].
Related Catalog	Research Areas >> Infection
In Vivo	Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1]. Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].
References	[1]. DB08792 [2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3.

Density	1.439g/cm3
Boiling Point	356.2ºC at 760 mmHg
Melting Point	175°
Molecular Formula	C₉H₉Cl₂NO₂
Molecular Weight	234.07900
Flash Point	169.2ºC
Exact Mass	233.00100
PSA	40.54000
LogP	2.15870
Index of Refraction	1.615

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE1970600

CHEMICAL NAME :: Acetanilide, 2,2-dichloro-4'-hydroxy-N-methyl-

CAS REGISTRY NUMBER :: 579-38-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H9-Cl2-N-O2

MOLECULAR WEIGHT :: 234.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962

Precursor 0
DownStream 1
CAS#:3686-72-4 [4-[(2,2-dichlo...

Diloxanid

Amebamida

EINECS 209-439-4

Diloxanide

RD 3803

Acetamide,2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl

Diloxanidum [INN-Latin]

Entamide

Ame-boots

Diloxanida [INN-Spanish]

DC Chemicals Limited
China
Product Name: RD 3803
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: diloxanide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Diloxanide

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