Diloxanide

Names

[ CAS No. ]:
579-38-4

[ Name ]:
Diloxanide

[Synonym ]:
Diloxanid
Amebamida
EINECS 209-439-4
Diloxanide
RD 3803
Acetamide,2,2-dichloro-N-(4-hydroxyphenyl)-N-methyl
Diloxanidum [INN-Latin]
Entamide
Ame-boots
Diloxanida [INN-Spanish]

Biological Activity

[Description]:

Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections. Diloxanide is an active luminal amebicide and hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate (HY-B1147)[1].

[Related Catalog]:

Research Areas >> Infection

[In Vivo]

Diloxanide is hydrolyzed in the gastrointestinal tract from its prodrug Diloxanide furoate[1]. Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats[2].

[References]

[1]. DB08792

[2]. D K Chatterjee, et al. Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models. Parasitol Res. 1987;74(1):30-3.

Chemical & Physical Properties

[ Density]:
1.439g/cm3

[ Boiling Point ]:
356.2ºC at 760 mmHg

[ Melting Point ]:
175°

[ Molecular Formula ]:
C₉H₉Cl₂NO₂

[ Molecular Weight ]:
234.07900

[ Flash Point ]:
169.2ºC

[ Exact Mass ]:
233.00100

[ PSA ]:
40.54000

[ LogP ]:
2.15870

[ Index of Refraction ]:
1.615

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE1970600

CHEMICAL NAME :: Acetanilide, 2,2-dichloro-4'-hydroxy-N-methyl-

CAS REGISTRY NUMBER :: 579-38-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H9-Cl2-N-O2

MOLECULAR WEIGHT :: 234.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,128,1962

Precursor & DownStream

Precursor

DownStream

Related Compounds

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