Diloxanide furoate

Names

[ Name ]:
Diloxanide furoate

[Synonym ]:
Amebiazol
Miforon
MFCD00083302
Diclofurazol
Diloxanid furoate
Furamide (amebicide)
Entamide furoate
Furentomin
Entamide 2-furoate
Histomibal
DILOXANIDE FUROATE
EINECS 223-108-1

Biological Activity

[Description]:

Diloxanide furoate is a luminal amebicide used in the treatment of Amebiasis, is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[References]

[1]. Castro Hermida JA, et al. Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate. Parasitol Res. 2001 Jun;87(6):449-52.

[2]. Martínez-Castillo M, et al. Flavonoids as a Natural Treatment Against Entamoeba histolytica. Front Cell Infect Microbiol. 2018 Jun 22;8:209.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₁Cl₂NO₄

[ Molecular Weight ]:
328.14700

[ Exact Mass ]:
327.00700

[ PSA ]:
59.75000

[ LogP ]:
3.26530

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1821800

CHEMICAL NAME :: 2-Furoic acid, ester with 2,2-dichloro-4'-hydroxy-N-methylacetanilide

CAS REGISTRY NUMBER :: 3736-81-0

LAST UPDATED :: 198608

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H11-Cl2-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LV1821800

Articles

Kinetic spectrophotometric H-point standard addition method for the simultaneous determination of diloxanide furoate and metronidazole in binary mixtures and biological fluids.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114 , 592-8, (2013)

Simple, reliable, and sensitive kinetic spectrophotometric method has been developed for the simultaneous determination of diloxanide furoate and metronidazole using H-point standard addition method (...

Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.

Pak. J. Pharm. Sci. 26(1) , 175-83, (2013)

This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetr...

A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)