Metoprolol Acid

Modify Date: 2024-01-09 20:07:19

Metoprolol Acid Structure
Metoprolol Acid structure
Common Name Metoprolol Acid
CAS Number 56392-14-4 Molecular Weight 267.32100
Density 1.159g/cm3 Boiling Point 477.1ºC at 760mmHg
Molecular Formula C14H21NO4 Melting Point 174-176ºC
MSDS USA Flash Point 242.3ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Metoprolol Acid


Metoprolol acid is a pharmacologically inactive urinary metoprolol metabolite.

 Names

Name atenolol acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.159g/cm3
Boiling Point 477.1ºC at 760mmHg
Melting Point 174-176ºC
Molecular Formula C14H21NO4
Molecular Weight 267.32100
Flash Point 242.3ºC
Exact Mass 267.14700
PSA 78.79000
LogP 1.44230
Index of Refraction 1.539
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY1634360
CHEMICAL NAME :
Benzeneacetic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-
CAS REGISTRY NUMBER :
56392-14-4
LAST UPDATED :
199110
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H21-N-O4
MOLECULAR WEIGHT :
267.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,186,1979

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport
RTECS CY1634360

 Articles5

More Articles
The impact of different proportions of a treated effluent on the biotransformation of selected micro-contaminants in river water microcosms.

Int. J. Environ. Res. Public Health 11(10) , 10390-405, (2014)

Attenuation of micro-contaminants is a very complex field in environmental science and evidence suggests that biodegradation rates of micro-contaminants in the aqueous environment depend on the water ...

Pregnancy-induced increase in metoprolol metabolism.

Clin. Pharmacol. Ther. 37(6) , 688-92, (1985)

Five women who developed hypertension during pregnancy received metoprolol, 10 mg iv; 3 days later they received metoprolol, 100 mg by mouth. Blood and urine samples were collected after each dose. Th...

Determination of two metoprolol metabolites in human urine by high-performance liquid chromatography.

J. Chromatogr. A. 309(1) , 198-202, (1984)

 Synonyms

2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetic acid
Metoprolol acid
SL 77-010
H 117/04
Atenolol acid
Atenolol Impurity 7